Neutrophil Changes Erythrocyte Changes Cytoplasmic vacuoles Crenated (burr cells, echinocytes) Loss of granulations Spherocytes Elongated nuclei Elongated (elliptocytes) (loss of segmentation) Undefined chromatin Schistocytes (fragments) (appear liquefied) Pyknotic nuclei (necrobiotic
) Hypochromic Cytoplasm rupture Smudge (basket) cells
The most common type of granuloma was tuberculous granulomas 63 (73.28%) followed by granuloma of cutaneous leishmaniasis 08 (9.30%), fungal granulomas 05 (5.81%), foreign body granulomas 04 (4.65%), leprosy 03 (3.84%) and one each (1.16%) of necrobiotic
granuloma, sarcoid granuloma and malakoplakia.
Right: (b) a higher power view demonstrating necrobiotic
granuloma comprising multinucleated giant cells (center of the image), surrounded by palisading histiocytes (magnification x200).
xanthogranuloma associated with systemic IgG4 disease.
In aquaculture, LAMP assays have been developed to detect fish and shellfish pathogens including aquatic DNA viruses such as red seabream iridovirus (RSIV) , white spot syndrome virus (WSSV) [10-14], koi herpesvirus (KHV, CyHV-3) [15-19], infectious hypodermal and hematopoietic necrosis virus (IHHNV) [20-22], hepatopancreatic parvovirus (PmDNV) , Singapore grouper iridovirus (SGIV) , acute viral necrobiotic
virus (AVNV) , turbot reddish body iridovirus (TRBIV) , infectious spleen and kidney necrosis virus (ISKNV) , lymphocystis disease virus (LCDV) , ostreid herpesvirus 1 (OsHV-1) , and soft shelled turtle iridovirus (sTiV) .
There were also distinct mature foci of necrosis surrounded by palisading histiocytes with an external corona of dense chronic inflammatory cells, mainly plasma cells, consistent with necrobiotic
granulomas of rheumatoid arthritis (see Figure 2).
In our studies we have shown that in the period of up to 30 days the main changes detected at this stage of restructuring were accompanied by necrobiotic
changes of preexisting bone and tumor.
Development of a monoclonal antibody specific to granulocytes and its application for variation of granulocytes in scallop Chlamys farreri after acute viral necrobiotic
virus (AVNV) infection.
(12,23) The bias of necrobiotic
lung nodules for peripheral or pleural locations and their ascribed waxing and waning course are of limited diagnostic value, even with known rheumatoid arthritis and subcutaneous necrobiotic
Rarely, paraproteinemias can develop similar lesions (known as necrobiotic
xanthogranuloma) that are associated with elevated blood levels of paraproteins.
During subsequent stages, the lesion invades deeper into mesenchymal tissues, leading to accumulation of necrobiotic
keratin debris in the newly formed central cavity; bone erosion and bone sequestra may also occur.
Other described histological reactions at injection sites include allergic contact dermatitis, lipogranulomas, local necrosis, sterile and infectious abscesses, necrotizing, necrobiotic
and sarcoidal granulomas, cutaneous lymphoid hyperplasia, lupus profundus-like and morphea-like reactions.
After a chapter on the structure and function of skin, volume one covers disorders of keratinization; inherited and autoimmune subepidermal blistering diseases; acantholytic disorders; spongiotic, psoriasiform, and pustular dermatoses; superficial and deep perivascular inflammatory dermatoses; granulomatous, necrobiotic
, and perforating dermatoses; inflammatory diseases of the subcutaneous fat; diseases of the oral mucosa; diseases of the genital skin; degenerative and metabolic diseases; cutaneous adverse reactions to drugs; neutrophilic and eosinophilic dermatoses; vascular diseases; idiopathic connective tissue disorders; and infectious diseases of the skin.
Microscopy findings included signs of focal encephalitis and vasculitis, lymphocytic perivascular inflammatory infiltration, profound degenerative and necrobiotic
changes of ganglion cells in the cerebral cortex, and signs of brain edema, as well as parenchymal myocarditis (stromal edema, degeneration of myocytes, foci of myolysis, and fragmentation of myofibrils).