In terms of the toxicologic effect of naphthoquinone
compounds, it was reported that ShD did not induce any hematologic toxicity in animal models, which indicates that ShD may be safe for use in vivo (31), whereas another report demonstrated toxicity in mice by intraperitoneal administration at a dose of 20 mg/kg for S, 41.0/22.75 mg/kg for AS, and 48 mg/kg for 3,3-[beta], [beta]-DMAS.
The insertion of a furan ring in the naphthoquinone
moiety increased the biological activity, and the FNQs were, in general, more active than the HNQs.
This may be related to the 2-hydroxy-1,4- naphthoquinone
A new chlorinated red naphthoquinone
from roots of Sesamum indicum.
derivative from Tectona grandis (Linn.).
(14) Vitamin K compounds share the same 2-methyl-1, 4-naphthoquinone backbone, yet differ by the substituent on the third carbon of the naphthoquinone
Vitamin K Vitamin K is a Required for the (naphthoquinone
) quinone compound in formation of the human body in a prothrombin (an storage form as essential component menaquinone (MK); of blood clotting).
have prepared naphthoquinone-amino acid conjugates starting from naphthoquinone
and L-amino acids by a Michael type mechanism in aqueous ethanol solution at RT in the presence of triethylamine .
Species are rich in flavonoids [1-4], carbonyl compounds, hydrocarbons , fatty acids , naphthoquinone
, tannins, alkaloids and amino acids [7,8].
(84) The active constituents in Pau d'arco are believed to be the naphthoquinone
derivative, lapachol, and its derivatives (ie.
Plumbagin (2-methoxy-5-hydroxy-1,4-naphthoquinone) is a natural naphthoquinone
possessing various pharmacological activities such as antimalarial (16), antimicrobial (17), anticancer (18), cardiotonic (19) and antifertility action (20).
SYNTHESIS OF A SERIES OF NAPHTHOQUINONE
SULFONIC ACID THIOSEMICARBAZONE LIGANDS AND REACTIONS WITH PALLADIUM (II).
Flavonol and naphthoquinone
glycosides of Drosera rotundifolia.
Effects of a naphthoquinone
analog on tumor growth and apoptosis induction.
fractions of stems a naphthoquinone
, 4-hydroxy-2-(2-methoxy-3-hydroxy-3-methyl- but-1-enyl)-4-hydro-1H-naphthalen-1-one as well as catalponol, catalponone, catalpalactone, a-lapachone, 9-hydroxy-a-lapachone, 4,9-dihydroxy-a-lapachone, 9-methoxy-a-lapachone, 4-oxo-a-lapachone, and 9-methoxy-4-oxo-a-lapachone of which catapalactone, 9-hydroxy-a-lapachone, and 4,9-dihydroxy-a-lapachone exhibited potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells (Park et al., 2010).