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  • noun

Synonyms for nadir

Synonyms for nadir

an extreme state of adversity

the point below the observer that is directly opposite the zenith on the imaginary sphere against which celestial bodies appear to be projected

References in classic literature ?
In the most illustrious lives as in the most obscure, in animals as in secretary-generals, there is a zenith and there is a nadir, a period when the fur is magnificent, the fortune dazzling.
Obvious predictive factors include pretreatment CD4 T cell nadir, plasma HIV RNA levels, and presence of drug-resistance mutations.
Possible reasons for the positive findings observed by Dybul and colleagues, (24) include different HAART study regimens, shorter treatment interruption, absence of drug-resistance mutations prior to study enrollment, higher CD4 T cell nadir, and history of IL-2 treatment in the majority of patients (patients in other comparable studies had no history of IL-2).