NSAID n (%) Celecoxib 16 (2) Ibuprofen 94 (12) Indomethacin 154 (20) Nabumetone
239 (31) Naproxen 264 (34) Salsalate 7 (1) Table 3.
NSAID classification Non-selective inhibition Acetic acid Proprionic acid Fenamate derivatives derivatives derivatives * Diclofenac * Fenoprofen * Meclofenamate * Etodolac * Flurbiprofen * Mefenamic acid * Indomethacin * Ibuprofen * Sulindac * Ketoprofen * Tolmetin * Naproxen * Oxaprozin Naphthyl alkanone Salicylates * Nabumetone
* Aspirin * Diflunisal * Choline magnesium trisalicylate * Salicylate Enolic acid derivatives * Piroxicam * Meloxicam Selective COX-2 inhibition * Celecoxib * Rofecoxib Table 9.
Comparative clinical trial of S-adenosylmethionine versus nabumetone
for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients.
Pulpdentine complex changes and root resorption during intrusive orthodontic tooth movement in patients prescribed nabumetone
In the first RCT, S-adenosylmethionine and nabumetone
were compared in an eight-week study.
While various authors have stated that NSAIDs should be used with caution during orthodontic tooth movement, a recent publication reported that nabumetone
, a drug belonging to the NSAID group, reduces the amount of root resorption along with the control of pain from intrusive orthodontic forces, without affecting the pace of tooth movement.
M2 EQUITYBITES-June 20, 2011-Watson Pharmaceuticals Inc awarded FDA approval for Nabumetone
for osteoarthritis and rheumatoid arthritis(C)2011 M2 COMMUNICATIONS http://www.
Several generic versions of Nabumetone
are already on the market under brand names including Relifex and Relafen.
The majority of participants (61 percent) reported regular use of NSAIDs within the previous ten years, including 48 percent who used aspirin, 18 percent who used ibuprofen, 5 percent who used naproxen and 4 percent who used nabumetone
Classification of NSAIDs according to COX-selective properties COX-1 selective Non-selective COX-2 selective Indomethacin Diclofenac Celecoxib Piroxicam Naproxen Etoricoxib Lornoxicam Ibuprofen Parecoxib * Tenoxicam Nabumetone
Rofecoxib ([dagger]) Ketoprofen Sulindac Valdecoxib ([dagger]) Ketorolac Lumiracoxib ([dagger]) Mefenamic acid Meloxicam * Parenteral formulation only ([dagger]) Withdrawn from the market, including South Africa.
dagger]) NSAIDs (diclofenac sodium, diclofenac potassium, diclofenac/misoprostol, etodolac, fenoprofen, flurbiprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, meclofenamate, mefenamic acid, meloxicam, nabumetone
, naproxen, oxaprozin, piroxicam, sulindac, tolmetin).
34,35) Because it is not a weak organic acid, at the pH of the stomach, nabumetone
is not highly lipophilic and, thus, does not penetrate the mucosal barrier, which is rapidly penetrated by all other available NS-NSAIDs in the presence of stomach acid.
Examples include Ibuprofen, Aspirin, Naproxen and Nabumetone
The non-selective NSAIDs examined in the review were diclofenac, etodolac, ibuprofen, indomethacin, ketoprofen, ketorolac, meloxicam, nabumetone
, naproxen, nimesulide and piroxicam (which is still being assessed)