were identified by the presence of either NaD channel clusters at the nodes of Ranvier (data not shown) or MAG clusters at the paranodal regions.
We have indeed shown this, by proving that the antibodies used for [P2Y.sub.12], recognizing either the C-terminus or these condintracellular loop of the receptor (Figure 1 and Table 1) and immunolabelling, respectively, microglia or myelinated fibers
in the CNS, are all still able to immunoreact for instance with platelets (Figure 5), where the receptor was originally described to be present and to have a role in the processes of activation, aggregation [46 49], primary hemostasis, and arterial thrombosis [50-55].
Tang and Nyengaard (1997) described a stereological method for quantitatively studying the white matter and the myelinated fibers
in the white matter of human brain.
Every untreated minute results in the loss of 2 million neurons, 14 billion synapses, and 7.5 miles of myelinated fibers
The sinusoidal waveform of the alternating current excites different subpopulations of nerve fibers as a function of frequency: 2,000 Hz, large myelinated fibers
; 250 Hz, small myelinated fibers
; and 5 Hz, small unmyelinated fibers.
are thought to be faster at conducting pain and other sensory stimuli than unmyelinated fibers.
All the case reports on this showed neuropathies with axon loss in myelinated fibers
. Why it affected only the autonomic system in this case is hard to say," she said.
The branch that connects the VIIth cranial nerve with the lesser petrosal nerve (from cranial nerve IX) apparently carries small myelinated fibers
that contain interspersed autonomic fibers from the auricular branch of cranial nerve X.
Percutaneous balloon microcompression is a procedure that selectively injures the large myelinated fibers
that mediate light touch and trigger the pain in all three sensory branches of the trigeminal nerve (Tekkok & Brown, 1996).
Light microscopic study of paraffin- and resin-embedded nerve disclosed a slight to moderate decrease in both small- and large-diameter myelinated fibers
. Surviving axons showed rare scattered examples of axonal degeneration, atrophy, secondary remyelination, and regeneration clusters.
Almost all white matter space is occupied by myelinated fibers
, each sheath having a thickness that relates to the caliber of its axon.
As noted above, loss of function after SCI is in large part due to damage to myelinated fibers
in ascending and descending tracts within the spinal cord.
This was confirmed by a previous study which proposed that activated astrocytes have positive effects on myelination and can promote the percentage of myelinated fibers
in CNS rat cultures (Nash et al., 2011).
Sural nerve biopsy revealed nerve demyelination, axonal degeneration, and an obvious loss of large myelinated fibers
, accompanied by Schwann cell proliferation and onion bulb formation.
Transplantation into the SCI of genetically modified by NT-3 gene human mesenchymal stem cells derived from umbilical cord blood has been demonstrated to reduce pathological cavitation, confer protection to myelinated fibers
, and promote functional recovery .