The Mouse asked at once after the third child's name.
'Cleangone!' repeated the Mouse. 'I do not believe that name has been printed any more than the others.
From this time on no one asked the Cat to stand godmother; but when the winter came and there was nothing to be got outside, the Mouse remembered their provision and said, 'Come, Cat, we will go to our pot of fat which we have stored away; it will taste very good.'
'Ah,' said the Mouse,' 'now I know what has happened!
'Cleangone' was already on the poor Mouse's tongue, and scarcely was it out than the Cat made a spring at her, seized and swallowed her.
`Are you--are you fond--of--of dogs?' The Mouse did not answer, so Alice went on eagerly: `There is such a nice little dog near our house I should like to show you!
Do come back again, and we won't talk about cats or dogs either, if you don't like them!' When the Mouse heard this, it turned round and swam slowly back to her: its face was quite pale (with passion, Alice thought), and it said in a low trembling voice, `Let us get to the shore, and then I'll tell you my history, and you'll understand why it is I hate cats and dogs.'
Male BALB/c and C57BL/6J mice were obtained from Harlan Olac (Bicester, UK) at 6 weeks of age and acclimatized for 1 week on Rat and Mouse
The body weight of each mouse
was measured three times a week for determination of treatment dose.
Rudolph, his colleague Rachel Jurd, and the rest of their team created a knockin mouse
bearing an amino acid-changing mutation in the beta subunit and then compared how normal mice and reacted to various anesthetics.
Applicants to this RFA are encouraged to propose risky approaches that incorporate broad knowledge of human cancer research into the design, analysis, and applications of mouse
cancer models, and to incorporate biocomputational, mathematical modeling, and systems biology strategies to inform design of genetic models and their cross-comparisons to human cancer.
's genes, however, proved easier to study and modify, so scientists deciphered the entire mouse
DNA sequence, or genome, before turning to the rat.
The mice had free access to water and a semi-purified diet (4% mouse
diet, #7001; Teklad, Madison, WI).
Further, the smaller size of the mouse
would mean that lesser amounts of chemical compounds would be required for testing.
The Columbia team wanted to know which genes switch on as a mouse
gradually fattens up.