As for the metastasis model, analysis of microvessel density
within the day 28 tumours showed an increased vessel area fraction (10.7 [+ or -] 2.9%; Figure 7(d)) in the tumour compared with the normal tissue in the contralateral striatum (3.6 [+ or -] 0.5%, p < 0.05; Figures 7(e)-7(f)).
At D3, the number of Ki67+/CD31+ cells in the peri-infarct area was not significantly different between PB-MNC+, PB-MNC, or PBS-treated mice (76.4 [+ or -] 15.3, 55.3 [+ or -] 22.3 and 56.9 [+ or -] 15.9 cells, resp.) (N = 4) nor was microvessel density
(14.4 [+ or -] 1.5 a.u., 15.0 [+ or -] 0.8 a.u., and 13.9 [+ or -] 0.4 a.u., resp.) (N = 4 - 5) (Figure 4).
The Scoring of Microvessel Density
was done as follows
A, immunostaining of vWF (green) with DAPI nuclear stain (blue) and lung microvessel density
. (B), pulmonary expression of vWF protein levels and lung microvessel density
Most commonly used methods consist of assessing microvessel density
(MVD) and expression of angiogenic factors, among which the most important are vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) [11,12,17].
Amerio, "Microvessel density
and VEGF expression seems to correlate with invasiveness of basal cell carcinoma," European Journal of Dermatology, vol.
Parecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, reduced lesion size, microvessel density
, the number of macrophages, and the expression of VEGF and led to atrophy and regression of endometrial implants in a rat model of peritoneal endometriosis .
Angiogenesis was evaluated by microvessel density
assay of frozen sections stained with anti-CD31 monoclonal antibody, which has a highly specific affinity for vascular endothelial cells.
VEGF expression has been shown to correlate with microvessel density
in a number of solid malignancies including carcinomas of the breast, and tissue concentration of this growth factor appears to be predictive of mortality associated with breast cancer.
(viii) PET and microvessel density
: "lung cancer AND PET or positron emission tomography AND microvessel density
OR MVD" (34 items)
On the other hand, for quantitatively assessing tumor angiogenesis, microvessel density
(MVD) is considered to be a valuable parameter.
However, Su et al .[sup] did not found any correlation of DCE-MRI parameters with microvessel density
and VEGF for assessment of angiogenesis in breast cancer.
Expression of cell adhesion molecules, CD44s and E-cadherin, and microvessel density
in invasive micropapillary carcinoma of the breast.
The mean microvessel density
(MVD) was assessed in the same manner as LVD.
The microvessel density
was calculated using a serological method.