The patient's history revealed 13-year seronegative arthritis, microcytic anaemia
diagnosed 10 years ago and general lymphadenopathy.
RDWI appeared to be the most reliable formula in differentiating BTT from IDA in patients with hypochromic microcytic anaemia
. For mass screening of microcytic hypochromic anaemia, this formula can be used in areas lacking facilities for Hb electrophoresis.
The prevalence of macrocytic, normocytic, and microcytic anaemia
is presented in Figure 5.
Patient Gender Age at the Clinical diagnosis symptoms (time to diagnosis) #1 Male 49 years Weight loss (3 years) (20 kg); microcytic anaemia
; metabolic bone disease #2 Male 53 years Weight loss (11kg); (12 months) diarrhoea; microcytic anaemia
; headache; dyspnoea; orthostatic hypotension; skin rash #3 Male 44 years Weight loss (6 months) (18 kg); diarrhoea; severe malabsorption; severe kwashiorkor-type malnutrition; metabolic bone disease #4 Female 58 years Arthralgias; (6 months) weight loss (10.5 kg); diarrhoea; malnutrition; microcytic anaemia
#5 Female 24 years ** Arthralgias; (12 months) peripheral and abdominal lymph nodes; muscle weakness; fatigue Patient Treatment Outcome * #1 i.v.
Mir Muhammad Sehto talked about "Comparison of microcytic anaemia
in primigradida and multigravida women".
The mean Hb concentration was 9.29 [+ or -] 1.8g/dL (range 4-14.1g/dL) and anaemia (Hb<11g/dL) was diagnosed in 81.4% of the children, a majority of whom had microcytic anaemia
. A negative correlation was observed between parasite density and haemoglobin concentration (r = -0.14).
An important pitfall to avoid is to regard all microcytic anaemia
as being IDA.
The elevated ZPP/H ratios is an indicator of microcytic anaemia
of iron deficiency.
mice have a mutation in Nramp2, a candidate iron transporter gene.
Deficiency of B6 results in hypochromic microcytic anaemia
due to impaired synthesis of the haem moiety of haemoglobin; erythrocytes are small and pale due to the low content of oxygenated haemoglobin.
There were 14 cases (6.4%) of ITP, 8 cases (3.6%) of ITP with megaloblastic anaemia, 12 cases (5.4%) of hypoplastic marrow and 12 cases (5.4%) of microcytic anaemia
. Bone marrow was normal in 6 cases (2.7%).
Our study demonstrates that the common morphology of anaemia among pregnant women was normochromic normocytic (in 68.9%), 1.4% having hypochromic microcytic anaemia
. Although we did not do iron studies to establish iron status, it has been reported that only 50% of cases of anaemia in pregnant women are responsive to oral iron.
The laboratory tests showed a hypochromic, microcytic anaemia
(Hb: 3.2g/dl, haematocrit 11.6, MCV 60.4 and MCHC 27.7).
However, a cohort study of 458 children aged between 1.8 and 7.5 years with mild hypochromic microcytic anaemia
reported that 243 children were confirmed with iron deficiency and 215 with beta thalassaemia.19 A study assessed age and gender variation, in relation to indices of iron metabolism in both groups and reported that age of IDA and beta - thalassaemia significantly affect reticulocyte indices.27
The blood count shows a hypochromic microcytic anaemia
with the Hb varying from 25 to 130 g/L and an increased RDW (1).