Infectious disease expert Albert Ko, a professor of epidemiology and medicine at the Yale School of Public Health, who was not involved in the study, said that during the 2015-2016 Zika epidemic, public health professionals were focused on the most severe birth defects, such as microcephaly
, but "we always suspected that was the tip of the iceberg."
The study published in the 'Journal of Experimental Biology' also added that only about five per cent of infants delivered by women with Zika is born with microcephaly
The finding that some children born with microcephaly
went on to develop normal head circumference by age 1 means that "microcephaly
is not necessarily static," Nielsen-Saines said.
The autosomal recessive form of primary microcephaly
(MCPH) is a rare genetic disorder that is characterized by head circumference less than three standard deviation below the mean from age and sex associated with mild to severe intellectual disability.1 Twenty four genes MCPH1-MCPH24 have been reported so far those may be involved in the underlying cause of autosomal recessive primary microcephaly
is a recent condition, there are few studies that describe the implications for the stomatognathic system (2,3,4).
Although some children with microcephaly
may have developmental disabilities, others do not have significant health problems.
Autosomal recessive primary microcephaly
, ASPM, Pakistan, MCPH, WES.
Several mechanisms involving virus genome sequences have been proposed to explain how Zika virus might cause microcephaly
A sensitivity analysis to address the concern about possible misclassification of microcephaly
at birth ** was performed by excluding infants with a birth head circumference measurement indicating microcephaly
and no other Zika-associated birth defects, who subsequently had normal neuroimaging and at least two postnatal measurements with a head circumference above the tenth percentile for the infant's age and sex.
The Zika website, available at www.zikarisk.com, is based on the Society for Maternal Fetal Medicine's Statement on Ultrasound Screening for Fetal Microcephaly
Following Zika Virus Exposure, (published in the February 2016 issue of American Journal of Obstetrics and Gynecology).
The birth rate drop correlated with the Zika-associated microcephaly
The linkage at MCPH5 locus was established in family B, associated earlier in causing microcephaly
with mutation in ASPM gene.
Zika-specific immunoglobulin M (IgM) and reverse transcription-polymerase chain reaction (RT-PCR) tests were conducted on serum from both microcephaly
and control infants, and cerebrospinal fluid samples only from infants with microcephaly
SINGAPORE, Dhu-AlQa'dah 24, 1437, Aug 27, 2016, SPA -- Singapore has confirmed its first case of a locally-transmitted Zika virus, which has been linked to microcephaly
, a rare birth defect, in Brazil, the health ministry said, Reuters reported.
The Texas Department of State Health Services confirmed that an infant with microcephaly
linked to the virus died shortly after birth. The fatality is the first Zika-related infant death in Texas.