Drug treatments for STZ-induced diabetic neuropathic pain included Pregabalin, Mexiletine
, and CC4148.
Intravenouslidocaine and oral mexiletine
block reflex bronchoconstrictionin asthmatic subjects.
Other drugs such as mexiletine
, clonidine, dextromethorphan, memantine, and capsaicin as well as nonsteroidal antiinflammatory drug (NSAID) group are also applied for the management of neuropathic pain.
A multi model approach towards pain management is increasingly used and it encompasses regional analgesia with continuous epidural or peripheral nerve block infusions, judicious opioids, acetaminophen, anti-inflammatory agents, anticonvulsants, ketamine, clonidine, mexiletine
, antidepressants and anxiolytics as options to treat or modulate pain at various sites of action 10.
other studies affirms the usefulness of some drugs or drug classes including Tricyclic agents, Gabapentin, Capsaicin, Mexiletine
, opiates and are antioxidants [3,20].
Good results have been obtained in the reduction of chronic pain after breast surgery with perioperative administration of venlafaxine, mexiletine
with gabapentin, a eutectic mixture of local anesthetics (EMLA), and a combined treatment with EMLA and gabapentin .
Digoxin and mexiletine
sensitivity in a collie with the MDR1 mutation.
Yararli etkileri olmakla birlikte, difenilhidantoin, karbamezepin gibi antikonvulsanlar, asetazolamid, "mexiletine
" ve immunomodulator tedaviler tum hastalarda etkili bulunmamistir (6,16,17).
On the other hand, Na+ channel blockers like mexiletine
and flecainide can shorten the action potential both in vitro and in vivo .
The analgesic effect of gabapentin and mexiletine
after breast surgery for cancer.
(1) Gene-specific therapy using potassium, spironolactone, mexiletine
, flecainide, nicorandil and other drugs is under evaluation.
Eighteen drugs are in Phase III development in the US including two GABA receptor agonists pregabalin (Pfizer) and gabapentin GR (Depomed); a sodium channel antagonist mexiletine
(Boehringer Ingelheim); three glutamate / NMDA antagonists ketamine intranasal (Javelin), a dextromethorphan/quinidine combination (Avanir), and NP-1 (EpiCept/Epitome); two serotonin/norepinephrine reuptake inhibitors desvenlafaxine (Wyeth), and paroxetine (GSK/Novo Nordisk); an alpha-2 adrenergic receptor antagonist/norepinehrine reuptake inhibitor reboxetine (Pfizer); an opioid receptor agonist/norepinephrine reuptake inhibitor tapentadol (Ortho-McNeil); a dopamine receptor agonist sodium oxybate (Jazz), and a neuromuscular blocking agent botulinum toxin A (Allergan).
Sodium channel block with mexiletine
is effective in reducing dispersion of repolarization and preventing torsade des pointes in LQT2 and LQT3 models of the long-QT syndrome.
"Therefore, concomitant use of tizanidine with other CYPA12 inhibitors, such as zileuton, other fluoroquinolones, antiarrhythmics (amiodarone, mexiletine
, propafenone, and verapamil), cimetidine, famotidine, oral contraceptives, acyclovir, and ticlopidine should be ordinarily avoided," the letter said.
is a local anesthetic, taken by mouth, which is similar to lidocaine and has been studied in symptomatic management of neuropathic pain of various ideologies.