methotrexate


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  • noun

Synonyms for methotrexate

toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid

References in periodicals archive ?
Wessels and associates first investigated the relationship between SNPs in five genes involving the adenosine pathway and the outcome of methotrexate treatment.
Lilly and Incyte previously announced that the study met its primary objective of demonstrating the non-inferiority of baricitinib monotherapy to methotrexate monotherapy based on ACR20 response rate after 24 weeks of treatment.
Women with a daily increase of 15% or more were treated with methotrexate.
A retrospective analysis evaluating compliance of innercity patients who received methotrexate at Bronx Lebanon Hospital Center in New York found that only 10% of patients were fully compliant with follow-up.
Ms Robinson added: "It's essential that patients who are about to start drugs such as methotrexate are given the right information about the benefits and potential harms of the drug, so that they can be involved in the decision to start taking it, and have the knowledge to take methotrexate safely and effectively.
Methotrexate Effects and Side Effects: A Mechanistic Perspective
Current management recommendations for intrathecal methotrexate overdose are based on case reports and small case series.
Although the Capizzi regimen has been very effective, improving cure rates for ALL by reducing relapses in the bone marrow where the disease initially occurs, the investigators hypothesized that a high-dose regimen of methotrexate would be more effective at targeting cancer cells in the central nervous system, where most B-cell ALL relapses occur.
The ministry confiscated all the Methotrexate drugs available in its different concentrations," said Abdel Rahman Shahin, official spokesperson to the Ministry of Health.
An inquest in 2008 ruled Mrs Froste's death had been partially caused by poisoning from Methotrexate which had been prescribed by Dr Singh.
He discussed giving her the drug methotrexate to terminate her pregnancy.
In the study involving nearly 1,200 patients, those who received Actemra by infusion every four weeks plus an older medicine, methotrexate, experienced significantly lower progression of joint erosion and joint space narrowing than those who received methotrexate and a placebo.
With time, knowledge of the pathophysiology of psoriasis improved, leading to the use of various other synthetic treatment agents, the most common being methotrexate (MTX), cyclosporin and fumaric acid.