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Words related to methapyrilene

antihistamine used to treat allergic responses (as rhinitis or dermatitis or pruritus)

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RESULTS: High-dose methapyrilene elicited hepatic damage that increased in severity with the number of doses, whereas no treatment-related lesions were observed in the kidney.
CONCLUSIONS: By factoring in dose level, number of doses, and tissue into the analysis of gene expression elicited by methapyrilene, we were able to identify genes likely to not be implicated in toxicity, thereby allowing us to focus on a subset of genes to identify toxicity-related processes.
KEY WORDS: DNA microarray, gene expression, hepatotoxicity, liver, methapyrilene, toxicogenomics.
Within the ILSI/HESI consortium, the hepatotoxicity working group evaluated the two hepatotoxicants methapyrilene (MP) and clofibrate by gene expression analysis of rat livers (Baker et al.
Morphology of early changes in liver carcinogenesis induced by methapyrilene.
To this end, members of the HWG developed standard experimental protocols for two prototypical hepatotoxicants: methapyrilene and clofibrate.
Methapyrilene was administered at 0, 10 or 100 mg/kg/day by gavage for 1, 3, and 7 days (Abbott Laboratories; Boehringer-Ingelheim Pharmaceuticals, Inc.
Several studies using microarrays have shown that changes in gene expression provide crucial information regarding the mechanism of toxicity induced by xenobiotic agents, including methapyrilene (MP), Aroclor 1254, and acetaminophen (Hamadeh et al.
When methapyrilene effects on the liver are examined, both histopathology and clinical chemistry analysis distinguished the high-dose animals from the low-dose and control animals.
The Hepatotoxicity Working Group of the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Committee on the Application of Genomics to Mechanism-Based Risk Assessment is investigating these factors by comparing high-density gene expression data sets generated on two sets of RNA from two independent in vivo experiments where rats were dosed with methapyrilene (MP) conducted at either Abbott Laboratories (site A; Abbott Park, IL) or Boehringer-Ingelheim Pharmaceuticals, Inc.
Caldesmon cDNA platform hybridization results showed decreases in gene expression levels for the high-dose methapyrilene 7-day pooled samples compared with their controls.
2004), One of these studies evaluated the effects of methapyrilene on rat hepatic gene expression as measured by both cDNA and synthetic oligo hybridization platforms.
In a proof-of-concept experiment on phenotypic anchoring, researchers in Richard Paules's NCT lab monitored liver toxicity in rats induced by the drug methapyrilene.
2002c), who were able to associate gene expression profiles with pathologic change in the liver after methapyrilene exposure.
8 (a) Saline Erythromycin 80 800 Saline Estradiol glucuronide 1 10 Saline Ethanol ND 3,000 Saline Etoposide 5 50 Saline Galactosamine 50 500 Saline Ibuprofen 20 200 Saline Indomethacin 2 20 Saline Iodoacetic acid 5 50 Saline Iron dextran 50 500 Saline Ketoconazole 30 120 Saline L-Ethionine 5 50 Saline Methapyrilene 5 50 Saline Methotrexate 50 250 Saline Microcystin 0.