In order to verify the influence of the flax shives extracts on the extracellular matrix remodelling in the human fibroblasts, the expressions of the genes coding for collagen type 1, alpha 1; collagen type 1, alpha 2; collagen type 3, alpha 1; matrix metalloproteinase 1; matrix metalloproteinase 2; and metalloproteinase inhibitor
1 were analyzed.
Inhibition of lymphangiogenesis-related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor
Several studies have shown that these proteins are either metalloproteinase inhibitors
(antihemorrhagic factors) or [PLA.sub.2] inhibitors (PLIs) (antineurotoxic/antimyotoxic factors) [8, 25-28].
Hoffman, "Matrix metalloproteinase inhibitor
BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice," Cancer Research, vol.
Marimastat is a broad-spectrum matrix metalloproteinase inhibitor
that blocks the activity of MMP-1, 2, 3, 7, 9, and 12  and has been shown to affect collagen remodeling in vitro.
Rat liver injury after normothermic ischemia is prevented by a phosphinic matrix metalloproteinase inhibitor
. FASEB J 16: 93-95.
Regulation of vascular smooth muscle cell migration and proliferation in vitro and in injured rat arteries by a synthetic matrix metalloproteinase inhibitor
. Arterioscler Thromb Vase Biol 1996; 16: 28-33.
The CCm-Tf-degrading activity in the samples from IPF patients was not altered by incubation on the CCm-Tf film coated with a mixture of aprotinin and elastinal (serine proteinase inhibitors) (Figure 5, B), but it was completely abolished in the film coated with a mixture of the serine proteinase inhibitors and 1,10-phenanthroline (a metalloproteinase inhibitor
) (Figure 5, C).
The strongest AMD genetic association found in the study was in a region on chromosome 22, near a gene called metalloproteinase inhibitor
In this nonrandomized, retrospective analysis from a study conducted to analyze the efficacy of a metalloproteinase inhibitor
for the treatment of osteoarthritis, the authors concluded that an NT-proBNP concentration [greater than or equal to] 100 ng/L was able to identify patients who had a nearly 2-fold risk for a cardiovascular adverse event.
Effect of a metalloproteinase inhibitor
on established corneal ulcers after an alkali burn.
He presented a secondary analysis of data from the multicenter, double-blind, prospective Prevention of MI Early Remodeling (PREMIER) study, a placebo-controlled trial that failed to show benefit for a matrix metalloproteinase inhibitor
. Of 2,498 participants, 362 were categorized as moderate, nonbinge drinkers prior to their MI.
Dupuytren's disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor
. J Bone Joint Surg Br.
British Biotech, Oxford, England, has reported the results of Study 131, a Phase III clinical trial of the oral matrix metalloproteinase inhibitor
Some analysts have said the success of Marimastat, known as a matrix metalloproteinase inhibitor
, is vital to the company's future.