In agreement with these studies, the most frequent potentially inappropriate medicine items prescribed for our population included oestrogen (oral and patch formulations), followed by non-steroidal anti-inflammatory drugs, meprobamate
and/or combinations thereof, amitriptyline and/or combinations, alprazolam, sliding-scale insulin, amiodarone and doxazosin.
admitted that he had consumed tramadol, procyclidine and meprobamate
The medications mentioned prominently in 1976 included among others, Flurazepam, triazolam, chloral hydrate, amylobarbitone, methaqualone, glutethimide, pentobarbital, methyprylone, secobarbital, tryptophan, meprobamate
, and the old standby, diphenhydramine.
nucifera (EECN) at 40, 60, and 80 mg/kg, ip, significantly enhanced the duration of sleep induced by pentobarbital (40 mg/kg, ip), diazepam (3 mg/kg, ip), and meprobamate
(100 mg/kg, ip) in mice, suggesting a probable depressive action on the central nervous system (41).
Amides are the main character of meprobamate
(tranquillizer) and sulfathiazole (bacteriostatic) synthetic drug .
Analyte Class Recovery % RSD (%) (N=4) Amphetamine Amphetamines 107% 3 MDEA 85% 4 MDMA 83% 4 Methamphetamine 102% 12 Buprenorphine Analgesics 87% 5 Tramadol 97% 9 Nordiazepam Benzodiazepines 106% 1 Temazepam 95% 2 Codeine Opiates 100% 10 Fentanyl Synthetic 100% 6 Meperidine Opiates 102% 9 Methadone 96% 2 Norfentanyl 82% 3 Normeperidine 101% 4 Propoxyphene 82% 9 Sufentanil 83% 11 Meprobamate
Other 85% 7 Phencyclidine 100% 2
Barbiturates, chloral hydrate, and non-barbiturate, non-BZD drugs such as meprobamate
are not recommended because of potential significant adverse effects and tolerance/dependence, and low therapeutic index.
Of the 61 analytes spiked into these 5 samples, buprenorphine (twice), norbuprenorphine (3 times), and norhydrocodone (4 times) failed to show a fragment ion, whereas meprobamate
and propoxyphene failed once each to show related protonated analyte.
Among these, the most commonly reimbursed tests for therapeutic drug monitoring showing at least a 50% change in reimbursement volumes from 2000 through 2010 were those for digoxin, phenytoin, valproic acid, tacrolimus, meprobamate
, carbamazepine, lithium, and vancomycin.
He was given the painkiller Equagesic, which contained both aspirin and the muscle relaxant meprobamate
. He went to lie down for a nap.
(23, 24) Felbamate and Meprobamate
are among Propanediol drugs previously shown to have anticonvulsant effects.
The electrochemical quantitative analysis of many drugs has been carried out by polarographic techniques, some of them are benzodiazepines (bromazepam, chlordiazepoxide, clonazepam, diazepam, dipotassium chlorazepate, flunitrazepam; flurazepam, lorazepam, medazepam, midazolam, nitrazepam, oxazepam, pinazepam, prazepam, temazepam, triazolam, clobazam), meprobamate
, phenothiazine- thioxantene- and butyrophenone-derivatives, sulpirid, reserpine, imipramine, thioridazine, amitriptyline, imipramine, opipramol, doxepine, chlorpromazine, levopromazine, perazine, prothipendyl, chlorprothixene, triperidol, methamphetamine .
Acute onset RBD is almost always induced or exacerbated by medications (especially Tri-Cyclic Antidepressants, Selective Serotonin Reuptake Inhibitors, Mono-Amine Oxidase Inhibitors, Serotonin Norepinephrine Reuptake Inhibitors,26 Mirtazapine, Selegiline, and Biperiden) or during withdrawal of alcohol, barbiturates, benzodiazepine or meprobamate
. Selegiline may trigger RBD in patients with Parkinson disease.
When these drugs, including the tranquilizers chlorpromazine (Thorazine) and meprobamate
(Miltown), gained FDA approval in the 1950s, psychiatry headed onto a new path: a biological and, unfortunately, pharmaceutical track for subduing mental symptoms.
Muscle relaxants such as cyclobenzaprine or metaxalone can be useful but carisoprodol is metabolized to meprobamate
, which is a tranquilizer similar to diazepam and may wisely be avoided (Zeigler 2005).