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Meperidine hydrochloride (Demerol[R]) has been used previously in PCA, but it has a high rate of adverse drug reactions and is contraindicated in patients with renal or hepatic dysfunction, seizures disorders, and those taking MAO inhibitors (Momeni, Crucitti, & De Kock, 2006).
As for resulting mortality among patients 50 years or older, the frequently-prescribed narcotic meperidine hydrochloride (Demerol) was mentioned in only eight medical examiner reports -- indeed, less than one-fourth the number of aspirin-related reports.
The company has been given approval for meperidine hydrochloride, a generic form of Demerol (Sanofi-Synthelabo Inc.).
The bulk narcotics business, now over 100 years old, is focused in two areas: natural narcotics, or opiates, used to produce codeine phosphate, morphine sulfate, hydrocodone bitartrate, oxycodone hydrochloride and other ingredients used in a variety of prescription pharmaceuticals, and a line of synthetic-based products, including propoxyphene and meperidine hydrochloride, naltrexone hydrochloride and methylphenidate hydrochloride, made from fine organic chemicals.