Thalassemic syndromes Heterozygous beta thalassemia Other hemoglobinopathies Artifact in the presence of Hb S Some Hb variants with thalassemic phenotype Acquired conditions Megaloblastic anemia
Hyperthyroidism Pseudoxanthoma elasticum Hypertrophic osteoarthropathy Treatment-related conditions Antiretroviral therapy in patients with HIV
Pancytopenia in chronic liver disease can be due to hypersplenism, megaloblastic anemia
, and primary marrow suppression.
Although vitamin [B.sub.12] deficiency is known to cause megaloblastic anemia
, our patient had an MCV within the reference interval, a slight increase of RDW-CV of 18.0%, and hemoglobin (Hb) within the reference interval at 13.6 g/dL.
Constantino, "Reduced erythrocytic deformability in megaloblastic anemia
," American Journal of Clinical Pathology, vol.
Hicks, "Apoptosis in megaloblastic anemia
occurs during DNA synthesis by a p53-independent, nucleoside-reversible mechanism," Blood, vol.
is a common early symptom leading to diagnosis, although neurological symptoms may occur in the absence of hematological abnormalities.[4,5] Although vitamin B12 cutoff values vary for each laboratory, serum values of less than 200 pg/mL is defined as vitamin B12 deficiency.
Key Words: Leukemia, Megaloblastic Anemia
, Aplastic Anemia
After blood transfusion, hemoglobin was at the same level, so a medullar aspirate was performed which raised the suspicion of iron-deficiency and megaloblastic anemia
. Bone biopsy was performed, showing bone fibrosis and hipocellularity of the bone marrow.
Diphyllobothriosis is notoriously known as a potential cause of vitamin B12 avitaminosis and megaloblastic anemia
of pregnancy: characteristics of pure megaloblastic anemia
and megaloblastic anemia
associated with Iron deficiency.
A syndrome of methylmalonic aciduria, homocystinuria, megaloblastic anemia
and neurologic abnormalities in a vitamin [B.sub.12]-deficient breast-fed infant of a strict vegetarian.
B Vitamins: A deficiency of B6 has been shown to depress immunity; lack of adequate vitamin B12 and folate can cause megaloblastic anemia
that depresses white blood cell counts; and thiamin, riboflavin and pantothenic acid each play a supporting role in optimal immune response.
Various underlying diseases known to cause RLS include iron deficiency anemia, (5) megaloblastic anemia
(vit B12 deficiency), kidney failure, (7-9) diabetes, (10,11) rheumatoid arthritis (12) and parkinsons disease, (13) multiple sclerosis (14) and venous insufficiency.
Such diverse pathologic causes can be present in different diseases such as aplastic anemia (AA), megaloblastic anemia
(MA), myelodysplastic syndromes (MDS), acute leukemia, hairy cell leukemia, myelofibrosis with myeloid metaplasia (MMM), lymphomatous or metastatic involvement of bone marrow, leishmaniasis, hemolytic diseases such as systemic lupus erythematous (SLE), hypersplenism and many other diseases.
Different types of anemia, including iron deficiency anemia (IDA), anemia of chronic disease (ACD), the combination of IDA and ACD (COMBI) anemia, megaloblastic anemia
, and hemolytic anemia, have been seen in patients with RA.