The basic investigation in the suspected cases of megaloblastic anaemia
with pancytopenia include complete blood counts, peripheral blood film examination, reticulocyte count and cobalamin and folate assay.
- Thiamine responsive megaloblastic anaemia
(Roger's syndrome) is an autosomal
A role for homocysteine increase in haemolysis of megaloblastic anaemia
due to vitamin B12 and folate deficiency: results from an in vitro experience.
in Chinese patients: a review of 52 cases.
It is a megaloblastic anaemia
, with high mean corpuscular volume and typical morphological features, such as hyperlobulation of the nuclei of the granulocytes (5).
is a type of anaemia caused by lack of vitamin B12 or folic acid.
Complete exclusion of animal foods from meals leads to vitamin [B.sub.12] deficiency which is likely to result in megaloblastic anaemia
, further affecting haemoglobin levels .
Pernicious anaemia is an inability for the body to absorb sufficient vitamin B12 into the body from the gastro-intestinal tract and accounts for 80% of all megaloblastic anaemia
. Vitamin B12 is essential in the body as it keeps the nervous system healthy and can be found in meat, eggs or dairy products.
In these cases, the commonest symptoms are nonspecific abdominal pain, nausea, vomiting, and iron deficiency or megaloblastic anaemia
.  Sometimes these hairballs result in weight loss, intestinal malabsorption or gastro-intestinal obstruction, perforation, abscesses, pancreatitis, obstructive jaundice, gastric emphysema and even death, especially in children.
is characterized by macrocytic red blood cells (RBCs) and typical morphological changes in the hematopoeitic precursors.
Prevalence of megaloblastic anaemia
in a pediatric unit.
Vitamin B12 deficiency is the primary cause of megaloblastic anaemia
He then showed slides of megaloblastic anaemia
and iron deficiency anaemia.
Fifty-two contributed chapters begin with coverage of stem cells and haemopoiesis, erthropoiesis, iron metabolism and disorders of haem synthesis, iron overload, and megaloblastic anaemia
; the collection concludes with primary immune thrombocytopenia, haemtological aspects of system disease, and of tropical diseases, and neonatal haematology.
Patients suspected of megaloblastic anaemia
on account of a raised mean corpuscular volume (MCV>110fl), were confirmed mostly by bone marrow examination or serum vitamin B12/folic acid assay in some of the cases.