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  • noun

Words related to megakaryocyte

a large bone marrow cell

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Intravital microscopy confirmed that neutrophil mobility was reduced in platelet-depleted mice where megakaryocyte volumes are increased.
Platelets and megakaryocytes. In: Lee GR, Foerster J, Lukens J, Paraskevas F, Greer JP, Rodgers GM, et al., editors.
Eltrombopag binds to the transmembrane portion of the TPO receptor (c-MPL) and stimulates the early to late stages of megakaryocyte maturation, resulting in production of platelets.
HE staining-detected changes are megakaryocyte and parallel megakaryocyte numbers in the spleen and femur [24, 25].
However, no significant difference was found among the genotypes on megakaryocyte count, disease severity, or drug response.
The switch discovered by Goldfarb's team controls whether the bone marrow produces cells called megakaryocytes of the type seen in adults or of the sort found in infants.
PMA was commonly used in induction of megakaryocyte differentiation from human leukemic cells, such as K562, MEG-01, and UT-7 cells in this study.
Previous studies have shown that both sympathetic transmitters (e.g., norepinephrine and epinephrine) and ROS promote proliferation of hematopoietic stem cells, their differentiation to megakaryocytes, and they induce megakaryocyte adhesion, migration, and proplatelet formation [33, 48].
Some data also suggest preferential expansion of the megakaryocyte cell lineage as a result of CALR's inability to export [Ca.sup.2+] from the ER, keeping the calcineurin-nuclear factor of activated T cells (NFAT) signalling pathway notably less active.
Megakaryocyte biology and the production of platelets.
These diseases also can trigger an up regulation of the megakaryocyte-platelet system, either through a direct effect on megakaryocyte, an effect on humoral effectors of endomitosis, or by damaging endothelium and thereby increasing platelet turnover [34].
The mesothelin precursor is a 69-kDa protein cleaved into a membrane-bound 40-kDa cell surface glycoprotein and a soluble 31-kDa N-terminal fragment referred to as megakaryocyte potentiating factor (MPF) or NH2-terminal-expressed in renal carcinoma (N-ERC)/mesothelin [2,7,11].
Immune thrombocytopenia (ITP) is an autoimmune disorder characterised by immunological destruction of platelets (primarily due to the production of platelet-reactive autoantibodies), along with an inability to compensate by increasing production of platelets as a result of immune-mediated megakaryocyte damage and dysfunction.[1] In ITP a platelet count of >30 x [10.sup.9]/L is generally the goal of treatment, but the decision to treat should be based on the patient's risk of bleeding, side-effects of medication and patient preference.[2] First-line treatment for ITP is with oral glucocorticoids.
Myeloid recovery was defined as an absolute neutrophil count of more than 500/[micro]L, and erythroid and megakaryocyte lineage reconstitution were defined as reticulocyte counts of more than 3 x [10.sup.4]/[micro]L and platelet counts of more than 20 000/[micro]L without the transfusion of platelet concentrates, respectively.