1--Ratio of mefloquine
concentrations in the erythrocytes and plasma of children and adults on D3 after the commencement of treatment.
Rhein, The Position of Mefloquine
as a 21st Century Malaria Chemoprophylaxis, Malar J, 9, 357 (2010).
CDC Update: New recommendations for mefloquine
use in pregnancy.
Though this mechanism is presented for chloroquine, it can be extrapolated to other antimalarial drugs like quinine and mefloquine
which are considered to have similar mechanism of action.
They ablate the transporter capacity to drift drugs, namely, CQ, quinoline (QN), mefloquine
(MQ), halofantrine (HF), and lumefantrine (LM), into the DV [33,34].
Documents recently acquired by Nevin indicate that Bales may have been taking mefloquine
before the murders.
One of the new compounds, when combined with mefloquine
, killed off all of the parasites in some mice with just a single oral dose and allowed those mice to live almost twice as long as those treated with conventional ACT.
A BOXED WARNING ABOUT POTENTIAL PSYCHIATRIC and nerve effects has been added to the label for the antimalarial agent mefloquine
Pharmacokinetic study of mefloquine
in Thai children aged 5-12 years suffering from uncomplicated falciparum malaria treated with MSP or MSP plus primaquine.
With failure rates ranging between 50 to 95% reported for chloroquine in parts of Nigeria (Falade et al, 2005; FMOH, 2004) and resistance to the classical antimalarial drugs, notably--chloroquine, sulfadoxine-pyrimethamine, mefloquine
, quinine been well documented (White, 1992; Krogstad, 1996).
Two of the most common agents--chloroquine and mefloquine
-are no longer effective in many parts of Mexico, Central and South America, the Middle East, sub-Saharan Africa, India, and Southeast Asia.
Among the perspectives covered are from breathing bad air to biting beasts, anti-microbials to anti-malarials, quinine to mefloquine
, qinghausu as the sweet wormwood of success, possible control by blocking transmission, and the dream of eradication.
The Defense Department forced all "war on terror" detainees at the Guantanamo Bay prison to take a high dosage of a controversial antimalarial drug, mefloquine
, an act that an Army public health physician called "pharmacologic waterboarding."
Resistance along the Thai-Cambodia border started with chloroquine, followed by resistance to sulfadoxine-pyrimethamine and mefloquine
, drugs that have been used to treat malaria for several years.