It should be noted that the 'typical' bone marrow abnormality seen in cyclic neutropenia, namely hypoplasia of the myeloid series with maturation arrest
at the myelocyte stage, was not seen in our patient; however, this occurs during the declining phase of the neutrophil oscillation, and myelopoiesis can be normal or even hyperplastic during neutrophil recovery.
One case of leucopenia showed maturation arrest
of myeloid precursors with reduced mature neutrophils and band forms in the marrow.
In six patients, maturation arrest
was observed at different steps of spermatogenesis and three patients showed SCO syndrome.
We believe that the lymphoblast-like cells observed in our patient's bone marrow were due to maturation arrest
in the normal lymphoblastic series caused by IVA.
The role of liver stem cells in the carcinogenic process has recently led to a new hypothesis that hepatocellular carcinoma in humans arises by maturation arrest
of liver stem cells.
These patients were divided into three groups according to testicular histology (hypospermatogenesis, maturation arrest
and germ cell aplasia) revealed in biopsy prior to ICSI.
But this maturation arrest
was not observed in low dose radiation group.
Section studied through separately sent testicular biopsy show features of incomplete spermatocytic maturation arrest
In a group of 135 men, sperm were found in 51% of men with Sertoli-cell-only pattern, 83% in men with maturation arrest
, and 100% of men with hypospermatogenesis.
Air-dried slides were stained with the May-Grunwald-Giemsa stain (BDH, Merck Limited, Mumbai, India) and reported as normal spermatogenesis, hypospermatogenesis, maturation arrest
or only Sertoli cells seen (19).