Bavarian Nordic said it had been selected by the Defense Threat Reduction Agency - which is part of the US Department of Defense - for the development of a vaccine against Burkholderia pseudomallei and Burkholderia mallei
which are seen as potential threats to national security.
even more challenging is the fact that human cases of glanders and melioidosis infections are not common in nonendemic parts of the world.
a Gram-negative, non- motile, obligate intracellular mammalian zoonotic pathogen.
is the etiologic agent of glanders, a disease primarily of equids, which is also communicable to man with fatal consequences.
at the Pinfang China Institute during World War II.
strain Bogor DNA in PCR-grade water in triplicate (Fig.
es transmitida por via digestiva, pero probablemente tambien por inhalacion y heridas.
Army Medical Research Institute of Infectious Diseases (USAMRIID) involved several pathogenic bacteria, including Burkholderia mallei
, the causative agent of glanders.
Multilocus sequence typing and evolutionary relationships among the causative agents of melioidosis and glanders, Burkholderia pseudomallei and Burkholderia mallei
Phenol-chloroform extraction of DNA from standard strains of Bacillus anthracis Vollum and Sterne, Yersinia pestis 0092, and Burkholderia mallei
(ATCC 23344) was performed as described previously (13) in a biosafety level III laboratory certified to work with select agents (registration number 20011016-798; entity number 020031123-0125).
Glanders, a World Organisation for Animal Health (OIE)-listed disease, is a contagious, life-threatening disease of equids caused by the gram-negative bacterium Burkholderia mallei
as a Category B agent by the US Centers for Disease Control and Prevention (2).
Development of a 5'-nuclease real-time PCR assay targeting fliP for the rapid identification of Burkholderia mallei
in clinical samples.
is currently hampered by a paucity of approved antimicrobial drug-selection markers.
To provide clinicians with guidance and a source of generally agreed-upon information, 10 different articles on 48 major agents have been compiled (Bacillus anthracis (anthrax), Yersinia pestis (plague), Francisella tularensis (tularemia), smallpox and monkeypox viruses, Clostridium botulinum (botulism), hemorrhagic fever viruses, encephalitis viruses, Coxiella burnetii (Q lever), Brucella species (brucellosis), Pseudomonas mallei
(glanders), and Pseudomonas pseudomallei).