malignant hyperthermia

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  • noun

Words related to malignant hyperthermia

hereditary condition in which certain anesthetics (e

References in periodicals archive ?
Carnitine palmitoyl transferase deficiency in malignant hyperthermia.
Mutations in three 'hot-spot' areas of the RYR1 gene have been shown to be functionally responsible for up to 50% of malignant hyperthermia susceptible (MHS) patients in European populations'.
The role of the skeletal muscle ryanodine receptor gene in malignant hyperthermia.
Malignant hyperthermia (MH) is a pharmaco-genetic disorder triggered by agents such as volatile anaesthetics and depolarising muscle relaxants that induce excessive calcium release from the sarcoplasmic reticulum (SR) in skeletal muscle (1).
One of the more dramatic was an unfortunate man who survived a lion attack in Perth, not a common event in that state, only to die subsequently of malignant hyperthermia (5).
Only minor complications arose in the postoperative period, and none suggested a malignant hyperthermia reaction.
He has devoted much of his professional career to enriching the understanding and treatment of the lethal malignant hyperthermia syndrome.
This novel porcine stress syndrome is not a malignant hyperthermia like the classical stress syndrome; it's a defect in dystrophin," Nonneman says.
Ryanodine receptor type 1 (RyR1) possessing malignant hyperthermia mutation R615C exhibits heightened sensitivity to dysregulation by non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95).
Patients who are malignant hyperthermia (MH) susceptible or have suspected MH susceptibility must be carefully managed during general anaesthesia, in order to avoid triggering a potentially fatal MH crisis.
He presents 22 crisis management protocols for cardiac, circulatory, airway, respiratory, metabolic, and drug-induced events, such as cardiac arrest, pediatric advanced life support, anaphylaxis, severe intraoperative ischemia, air embolism, difficult mask ventilation and intubation, laryngospasm, aspiration, post partum hemorrhage, neonatal resuscitation, and malignant hyperthermia, with instructions and details for each, a terminal event checklist, and a crisis prevention guide.
The mutation is associated with malignant hyperthermia, a life-threatening inherited disorder of skeletal muscle in which commonly used general anesthetics trigger uncontrolled muscle contractions and dangerous increases in body temperature.
Common causes of the latter include traumatic crush injury, acute muscle ischemia, seizures, excessive exercise, heat stroke or malignant hyperthermia, intoxications (eg, alcohol, cocaine), and infectious or metabolic disorders.
Malignant hyperthermia is caused by a genetic defect of muscle metabolism.
63) These agents can also trigger malignant hyperthermia.
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