Clinical assistance protocol for the management of malignant hyperthermia
. Rev Esp Anestesiol Reanim 2017; 64:32-40.
Change ExACAF gnomAD AF Rare 3 P1763S 6.60E-05 1.62E-04 6 P3410L 2.47E-05 1.29E-04 10 R3337Q 16 T1738K 22 N1383S 8.24E-06 26 G169R 9.52E-04 2.93E-04 Common 3 hets I359L 0.064 0.048 10 hets and 1 0 horns P34S 0.204 0.192 13 hets and 3 horns Disrupt 0.265 Individual CADD SIFT PP2 Rare 3 22.9 T D 6 25.8 D D 10 23.2 D D 16 25.5 T D 22 26.1 D D 26 24.4 D D Common 3 hets 20.4 D B 10 hets and 1 0 horns 24.9 D D 13 hets and 3 horns 3.375 Individual Drug interaction Rare 3 Some variants in this gene can cause malignant hyperthermia
in response to some anesthesia.
: pharmacology of triggering.
Pending confirmation, the patient's medical record mentions suspicion of MH susceptibility and treatment with dantrolene for malignant hyperthermia
. This information will remain in the patient's permanent medical record and could be viewed as a preexisting condition.
Functional and genetic characterization of clinical malignant hyperthermia
crises: A multi-centre study.
Banney, "Firefighting and malignant hyperthermia
," British Medical Journal (Clinical Research Edition), vol.
Heiman-Patterson, "Neuroleptic malignant syndrome and malignant hyperthermia
. Important issues for the medical consultant," Medical Clinics of North America, vol.
Other differential diagnoses such as malignant hyperthermia
and neuroleptic malignant syndrome were ruled out due to normal creatinine kinase level (81 units/L; normal 20-200 units/L) and lack of causative medication.
Mimics include neuroleptic malignant syndrome, malignant hyperthermia
, thyroid storm, drug fever, hypothalamic brain stem stroke, heat prostration, cancer, trauma, pancreatitis, seizures, CNS infection, and endocarditis.[sup] In this case, the patient was febrile and not sedated; there were no focal signs, no meningeal signs, no trauma, whereas Confusion Assessment Method indicated delirium, therefore SAE was likely.
The death certificate mentioned the cause of Fatmah's death as malignant hyperthermia
, a life-threatening condition where the body temperature shoots up and the muscles severely contract when given general anaesthesia.
Their topics include the pretreatment evaluation of the dental patient, essentials of an emergency kit, acute chest pain, allergy and anaphylaxis, nausea and vomiting, hemorrhagic emergencies, emergencies in the pregnant dental patient, hypertension and hypotension, diabetic emergencies, malignant hyperthermia
, local anesthesia emergencies, and basic life support.
However, succinylcholine administration may be associated, at times, with side effects such as postoperative myalgia, malignant hyperthermia
, masseter spasm, histamine release, anaphylaxis, hyperkalemia, cardiac arrhythmias and increase in intracranial or intraocular pressure.
Due to its efficacy in anesthetic-induced malignant hyperthermia
, the muscle relaxant dantrolene has been used in the treatment of NMS.
is an inherited autosomal life threatening skeletal muscle disorder usually triggered by certain general anesthetic drugs like volatile anesthetics and depolarizing muscle relaxants (succinylcholine).
[4,11] (b) Malignant hyperthermia
shares two core symptoms with NMS--hypothermia and muscle rigidity [12,13]--but, unlike NMS, the other common symptoms of malignant hypothermia include hemoglobinuria, myoglobinuria, heart abnormalities (induced by hyperkalemia), and cyanosis.