Inflammatory and malignant histiocytosis
. Williams haematology, 8th Edition: 1047-1064.
Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histiocytosis
. Cancer 1979;44:993-1002http://dx.doi.org/10.1002/1097-0142(197909)44:3<993::AID-CNCR2820440329>3.0.CO;2-5.
Patients with infection-associated HLH usually have persistent unexplained fever, cytopenia, lymphadenopathy, and, frequently, hepatosplenomegaly and coagulopathy, causing diagnostic difficulties with malignant histiocytosis
or T-cell lymphoma (2).
The Working Group of the Histiocyte society has divided histiocytic disorders into 3 different groups 1) dendritic cell histiocytosis 2) erythrophagocytic macrophage disorders and 3) malignant histiocytosis
. Langerhans cell disease belongs to group 1 and encompasses a number of diseases (2).