production by human T cells in disease states.
T lymphocytes, especially [CD4.sup.+], play important role in wound healing by secreting lymphokines
to activate fibroblast, as wound anti-inflammatory agent, and activate factor in major histocompatibility complex (MHC) class II.
Anderson, "Effects of products of activated leukocytes (lymphokines
and monokines) on the growth of malignant trophoblast cells in vitro," American Journal of Obstetrics and Gynecology, vol.
Coffman, "TH1 and TH2 cells: different patterns of lymphokine
secretion lead to different functional properties," Annual Review of Immunology, vol.
Feddleston, "Immunotherapy for cancer: the use of lymphokine
activated killer (LAK) cells," Gut, vol.
Corticosteroids, through their immunosuppressive and antiinflammatory effects, impair antibody formation and cell- mediated immunity that tuberculosis requires for its control.13 Glucocorticoids inhibit the lymphokine
effect and monocyte chemotaxis and also block Fc receptor binding and function.13 Glucocorticoids depress the number of peripheral blood monocytes as well as monocyte functions, including bactericidal activity and production of interleukin-1 and TNF-a.
The increase in cortisol during exercise is mediated by a lymphokine
, interleukin-6 (IL-6) (8).
Increased expression of [alpha]1,2-fucosylated glycans on the surface of rat colon carcinoma cells on transfection with the FUT1 gene is associated with tumorigenicity and an increased resistance to apoptosis  and lymphokine
activated killer cytotoxicity, but not to natural killer cell lysis .
Some of these defector molecules, migration inhibition factor (MIF) a lymphokine
, inhibit the migration of macrophages in the same culture medium .
Swainsonine has been shown to reduce tumor cell invasion in Phase I human cancer trials and to enhance the natural antitumor defenses of the body, such as lymphokine
activated killer cell (LAK) and natural killer cell (NK) cytotoxicity (Galustian et al.
(132) This property of lymphokine
overproduction was valuable because
The improvers showed significant rises in natural killer (NK) cell counts, HSV specific lymphokine
activated killer (LAK) activity, and reduced levels of anxiety when compared to non-improvers.
(20.) Tvede N, Kappel M, Halkjaer-Kristensen J, Galbo H, Pedersen BK.The effect of light, moderate and severe bicycle exercise on lymphocyte subsets, natural and lymphokine
activated killer cells, lymphocyte proliferative response and interleukin 2 production.
Growth inhibition of Trypanosoma cruzi in cultured murine myocardial cells mediated by a specifically induced lymphokine