It was evaluated that except pravastatin and lovastatin
, alternate-day therapy was as effective in lowering total cholesterol (TC), low density lipoprotein (LDL) cholesterol and triglycerides (TG) as the standard daily dosing.
"If used according to their suggested serving sizes, only two of the nine red yeast rice supplements we tested would provide amounts of lovastatin
known to lower cholesterol," said ConsumerLab President Tod Cooperman, MD.
80 mg, pravastatin 20 mg, and simvastatin 10, 20, and 40 mg, we observed marginal statistical significance.
However, most of the comparisons especially contain pitavastatin, lovastatin
, and fluvastatin are too small to as direct evidence.
As a consequence, simvastatin and lovastatin
are widely considered contraindicated in HIV-positive patients.
Some strains of red yeast rice (but not those sold as food in China and Japan), when fermented under controlled conditions, produce compounds called monacolins, which are structurally very similar to statin drugs such as pravastatin, simvastatin, and lovastatin
. Indeed, lovastatin
has been identified as the most predominant monacolin in red yeast rice, although up to 10 distinct monacolins have been found in some products.
Some recent research suggests that low-to-moderate consumption of grapefruit may be safe for lovastatin
This natural occurring lovastatin
is quite different than a synthetic statin.
formulations took the top two spots, with Vytorin at the top of the brand list and lovastatin
, the generic for Merck's Mevacor, at the top of the generics list.
(1) The increased risk was similar for lipophilic (pravastatin, rosuvastatin) and hydrophilic (atorvastatin, simvastatin, lovastatin
) statins, although the analysis wasn't adjusted for doses used.
In the present investigation, an attempt has been made to determine whether an ethanolic extract of Piper betle and its active constituent, eugenol, possess putative serum lipid-lowering and antioxidant activities in comparison with that of lovastatin
(a commercially available serum lipid-lowering drug) in an experimental animal model of hypercholesterolemia.
On the other hand, lovastatin
reduces the inflammation in animals .
Researchers reviewed data from 135 studies to evaluate the safety of seven statin drugs: atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin
(Mevacor), pitavastatin (Levalo), pravastatin (Pravachol), rosuvastatin (Crestor) and simvastatin (Zocor).
The study, however, showed that lesser-prescribed lovastatin
at a higher dose was positively associated with dementia development.
Almost all the statins (except lovastatin
) decreased the risk for new onset dementia when taken at higher daily doses.