Next, keratinocyte-derived IL-23 may contribute to the accumulation of Th17 cells and the overproduction of IL-17 in the local lesion
Even in a recently vaccinated person, a response to an infection of such high magnitude will most likely result in a local lesion
. However, the question of whether a major reaction with severe symptoms would emerge in this hypothetical situation remains.
(2) Neoplastic disease of the spine may arise either as a local lesion
developing within or as an extension from adjacent or distal organs.
The Infinium HumanMethylation450 BeadChip array has been widely used to study DNA methylation in human tissues. To the best of our knowledge, there is no report on DNA methylation in local lesions
of patients with NSCL.
Chemotherapy is the treatment option for a multifocal disease, radiotherapy for lesions that cause organ dysfunction, and corticosteroids for local lesions
If the combined treatment is found to be either equally or more effective, then it will be recommended for the treatment of local lesions
due to low cost and high efficacy.
In view of the severity of local lesions
caused by bothropic envenomation, which often leads to permanent tissue damage, new therapy options are important to provide complementary treatment to antivenom application.
AltMV is known to manifest a wide range of symptoms including chlorotic spotting of various size, chlorosis, chlorotic local lesions
, leaf distortion and curling, mosaic, mottle, necrotic spotting of various size, necrotic ringspots, rugosity, veinal necrosis, and interveinal yellowing (Table 2) [1, 2,12,15,17].
Each case studied had elaborate history taking, a thorough general physical examination was done along with meticulous examination of the local lesions
. Relevant lab investigations were carried out.
Removing ticks whole from the affected tissue is of utmost importance in the prevention of tickborne diseases and possible abscess, granuloma, or other local lesions
. Therefore, ticks should be removed immediately and carefully from affected tissue.