The macroscopic histological features of NCM have been described as thickening of the leptomeninges
by infiltrative tumour cells with predilection for the basal surface of the brain as well as the rostral portion of the brain stem.
Infiltration of the leptomeninges
by systemic cancer: A clinical and pathologic study.
Biopsy of the brain surface and leptomeninges
was performed on the left frontal cortex and sylvian fissure proceeded by a small frontotemporal craniotomy.
 Failure of its regression results in residual vascular tissue which forms angiomas of leptomeninges
, face and ipsilateral eye.
Kadmon is conducting ongoing Phase 2 clinical trials of tesevatinib for the treatment of EGFR-mutation-positive NSCLC that has metastasized to the brain and/or the leptomeninges
and for the treatment of glioblastoma.
Postmortem biopsies of the brain and meninges demonstrated a mild infiltrate of atypical lymphoid cells within the blood vessels of the leptomeninges
. Stains demonstrated a reactive process that featured a predominance of T cells and no demonstration of clonality.
(Figure 2A) and (Figure 2B) reveal enhancement of the leptomeninges
over the cerebellum.
It is defined as lymphoma developing in the brain, leptomeninges
, spinal cord or eyes without evidence of lymphoma outside the CNS.
Leptomeningeal metastasis (LM) is the metastatic dissemination of malignant cells to the leptomeninges
and subarachnoid space of the central nervous system.
Unlike IDBC, however, ILBC has a predilection for metastasis to the abdomen, peritoneum, and leptomeninges
. Intra-abdominal metastases may be insidious and difficult to differentiate histologically from gastric adenocarcinoma .
New studies have now shown that TLR4 is also expressed on CNS structures such as choroid plexus, circumventricular organs, and leptomeninges
Cerebral amyloid angiopathy (CAA) has been recognized as one of the morphologic hallmarks of Alzheimer disease (AD), resulting from deposition of amyloid in the media and adventitia of small arteries and capillaries of the leptomeninges
and cerebral cortex, which is associated with cerebral microbleeds and white matter hyperintensities .
In 2 other RMS cases we dealt only with leptomeningeal spread in the brain and in the spinal cord (Figure 5); in one of them only the leptomeninges
surrounding the left complex of VII and VIII cranial nerves were involved (Figure 6).