One of the most challenging issues in the development of inhalation drug products is the control of extractables and leachables
instability interactions are much more prevalent problems than direct leachable
Structured around a logical framework for an extractables and leachables
safety assessment and closely linked to the pharmaceutical product development process, Compatibility of Pharmaceutical Products and Contact Materials directly addresses the fundamental questions of "what activities need to be performed to completely, efficiently, and effectively address the issue of product safety from an extractables and leachables
The CCS compatibility is defined by the leachable
qualification, and the mechanism for qualification relies on knowledge of the chemical characterization of all critical CCS components, the probability of migration and impact to patient safety.
Forward-looking statements in this news release include: that MSRDI has been contracted to continue with metallurgical testwork (bottle roll tests followed by column tests) to determine additional parameters for an SX/EW heap-leach operation at the Hill Copper Leach Project; that the Company intends to begin drilling within the next sixty days subject to drill rig availability; that the Company intends to commission a pre-feasibility study and NI 43-101 resource estimates in 2008 and 2009 on the leachable
and sulfide zones of the Hill Copper-Zinc Project; and, that the Company intends to log, sample and assay approximately 20,000 feet of the historic drill core acquired in 2007.
In addition, more than half of the material that would have to be stripped to access the new deposit is leachable
material that can be utilized in the future for low cost SX-EW production.
Forward-looking statements in this news release include: that the acquisition of nearly 77,000 feet of drill core carried out by two previous explorers provide a significant cost savings in drilling expenditure and time savings; that new assay results could also provide a more definitive boundary between leachable
resources of copper and zinc; and that assay results will significantly increase the overall copper-zinc-silver and gold resources of the Hill Copper-Zinc Project.
Distinct zones of highly leachable
copper appear both at the top of the deposit near surface, as well as at depth.
Candente has an advanced exploration stage leachable
copper project, Canariaco, and several other gold, copper and silver projects in Peru.
The following table summarizes the results for the 11 column tests that evaluated the leachable
Near surface leachable
copper zone expanded by 250 m to the east, 250 m to the west and 150 m to the north
Tests indicate 54% of total copper is readily leachable
, but gold and molybdenum are not recoverable by conventional copper leaching processes.
The autoclave can also provide a source of ferric sulphate that will leach residual secondary copper sulphates not readily leachable
by acid alone in the current circuit design.
The analytical services span analytical method development, validations and optimization; identification and isolation of trace level impurities; method development and quantification of genotoxic impurities and heavy metals; characterization of polymorphs/pseudo polymorphs; stability studies for drug product and drug substance as per ICH guidelines; dissolution profile; extractable and leachable
study & quantification; and particle size distribution analysis.
The heap-leach operation will continue in parallel with the planned sulphide operation as long as leachable
ore is available.