Indian red scorpion (Buthus tamulus) venom-induced augmentation of cardiac reflexes is mediated through the mechanisms involving kinins
in urethane anaesthetized rats.
have a protective effect on the myocardium with B2R activation (27, 28).
It may be due to its local anesthetic action or by inhibition of kinin
The role of kinin
receptors in cancer and therapeutic opportunities.
Examination of genetic variants involved in generation and biodisposition of kinins
in patients with angioedema.
derived from kininogen produced by tissue kallikrein (TK) exert a broad spectrum of cellular functions via activation of the bradykinin B1 or B2 receptor (B1R or B2R, resp.
are a group of peptides with a potent vasodilator effect.
The combination of an allergen with specific IgE fixated to tissue mast cells or to circulating basophiles provokes the releasing of histamine, serotonin and kinins
, minutes after ingestion, or even hours after contact (ISHIZAKA & ISHIZAKA, 1967; GASCHEN & MERCHANT, 2011).
They are mostly due to the production of kinins
and cytokines by the leaked blood.
The tolerability profile of ACE inhibitors is marked by a considerable incidence of cough, affecting up to 35% of patients 34 The cough occurring with ACE inhibitor therapy is related to increased levels of kinins
, and it is the most frequent reason for discontinuation of treatment with an ACE inhibitor.
The pain of Dry socket occurs because of release of kinins
which are immediately available following tis- sue trauma,2 exposure of nerve endings to air, food and fluids in bare bone of the extraction socket1 and infec- tious process which releases tissue activators and pain mediators.
These substances (histamine, kinins
, potassium, and prostaglandins) stimulate the nociceptors at the related area and lead to local sensitivity.
The first phase is mediated through the release of histamine, serotonin and kinins
whereas the second phase is related to the release of prostaglandin and slow reacting substances which peak at 3h (Vinegar et al.
The ground substances changes may be a direct result of the insulting agent or may be mediated via histamines or kinins
First phase occurs within an hour of injection of phlogistic agent and is mediated through release of histamine, serotonin and kinins
while the second phase (3 to 4 hours) is related to release of prostaglandins .