Essential roles of Drosophila inner centromere protein (Incenp) and Aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore
disjunction, and chromosome segregation.
de Mey, "Taxol induces the assembly of free microtubules in living cells and blocks the organizing capcity of the centrosomes and kinetochores
," Proceedings of the National Academy of Sciences of the United States of America, vol.
The ultrastructure of the diffuse kinetochore
in Luzula nivea.
During the prophase of meiosis I, the synapsed chromosomes form a bivalent structure that also has one exposed minus-face kinetochore
and one exposed plus-face kinetochore
These studies allowed us to gain deep knowledge on such important problems as: attachment of kinetochores
to the spindle, kinetochore
orientation and re-orientation during prometaphase I and metaphase I, in vivo orientation and segregation of the X chromosome, autosomal univalents, multiple chromosomal configurations (e.
Loss of genomic integrity has been attributed to hypomethylation of repetitive elements, which can lead to inappropriate recombination resulting in defects in cell cycle monitoring check point genes as well as genes involved chromosome condensation, kinetochore
structure and function, and centrosome and kinetochore
The conserved kinetochore
protein shugoshin protects centromeric cohesion during meiosis.
This control can be disrupted by interfering with DNA repair, kinetochore
assembly, checkpoints, centrosome duplication, microtubule dynamics and numerous other cellular maintenance processes (42).
Holocentric chromosomes exhibit kinetochore
along the major part of their length.
is the part of the centromere to which spindle fibers attach during cell division.
1984) reported that the chromosomes of common buckwheat are similar to each other in size and all have a median kinetochore
When metaphase-arrested oocytes of Chaetopterus were exposed to colchicine, the spindle birefringence gradually disappeared as the fibrils depolymerized (the kinetochore
fibers were the longest to persist), but the depolymerizing filaments actually led the chromosomes and inner spindle pole to the cell surface, where the outer meiotic spindle pole was attached.
The CENP-A deposition machinery is recruited to centromeres in a cell cycle-regulated manner by inner kinetochore
proteins associated with CENP-A, most notably CENP-C.
The inner kinetochore
directly binds to the centromeric chromatin during the whole cell cycle.
fibers form among interacting sets of microtubules of the QMS, astral microtubules radiating from the poles gradually disappear (Fig.