kinetochore


Also found in: Dictionary, Medical, Encyclopedia, Wikipedia.
Related to kinetochore: centrosome
Graphic Thesaurus  🔍
Display ON
Animation ON
Legend
Synonym
Antonym
Related
  • noun

Synonyms for kinetochore

a specialized condensed region of each chromosome that appears during mitosis where the chromatids are held together to form an X shape

References in periodicals archive ?
Interestingly, CENP-E is involved in the initial alignment of chromosomes at the spindle equator on the metaphase plate, and therefore, it is required for steady spindle microtubule capture at the kinetochores, which is a critical step in proper chromosome congression during prometaphase.
Tan, "Autoantibody to centromere (kinetochore) in scleroderma sera," Proceedings of the National Academy of Sciences of the United States of America, vol.
[gamma]H2AX is an early indicator of DNA damage [31], and we previously suggested that [gamma]H2AX plays an important role in both DDR [28] and SAC by contributing to the recruitment of both TTK and MAD2L1 to the kinetochore during metaphase [38].
The effect of centromeric ncRNAs on chromosome structure and segregation was analyzed by staining with specific antibodies for proteins or histone modifications involved in the kinetochore formation and the control of cell cycle progression.
Essential roles of Drosophila inner centromere protein (Incenp) and Aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation.
In holokinetic chromosomes, the kinetochore plate covers a significant portion of the chromosome length (Wolf 1996).
• Ready-To-Use Vectors for Live Cell Imaging of Nuclear Proteins - Coding for Kinetochore, Chaperone, Histone, Mitotic Checkpoint, Mis12 Complex, and Hec1 Complex Proteins
Target functions include kinetochore and sister chromatid stabilization; S-phase signaling and G1-S regulation; transcription factors controlling cell cycle progression, epigenetic regulation, membrane oncogenes, and release of metabolic growth factors; and morphogenesis/cytoskeleton organization.
Gene set seed p value Neurite outgrowth 3.36E - 06 Regeneration 3.87E - 05 Kinetochore assembly 8.02E - 04 Hair cell differentiation 9.68E - 04 Olfactory bulb development 9.79E - 04 Organogenesis 9.96E - 04 Sertoli cell proliferation 1.10E - 03 Spindle assembly 1.72E - 03 Neural crest cell development 2.18E - 03 Chondrogenesis 2.41E - 03 Ureteric bud branching 2.76E - 03 Protein polyubiquitination 2.79E - 03 Ion channel clustering 2.85E - 03 Chondrocyte differentiation 2.86E - 03 Cytokinesis 2.86E - 03 TABLE 3: Immunohistochemistry results for KIF3A, KIT, KRT20, and MUC1.
Taxane based chemotherapy, for example, pacilitaxel, is a common therapy for cancer as by increasing microtubules and it blocks the organization of the centrosome and kinetochore thereby inhibiting mitosis [99].
At day 1 after enucleation, 85 genes have been up-/downregulated, while at day 15 of the process only 7 such genes have been found, among them genes directly involved in cell cycle regulation, for example, cyclins (cyclin E1, E2, and B1), cyclin-dependent kinases (Cdk6 and Cdk1)--enzymes that regulate transcription, mRNA processing and progression of cell cycle, also enzymes involved in separation of sister chromatids during anaphase, centromere proteins (Cenpe and Cenpf), and kinetochore proteins (Ska3).
Induction of kinetochore-positive and kinetochore -negative micronuclei in CHO cells by ELF magnetic fields and or X-rays.
These chromosomes have a diffuse centromere (the non-localized centromere, diffuse kinetochore), contrary to monocentric chromosomes with a localized position of the centromere, prevailing in the plant kingdom.
The Caenorhabditis elegans kinetochore reorganizes at prometaphase and in response to checkpoint stimuli.
The centromere is the chromosomal domain that directs the formation of the kinetochore, a proteinaceous structure that interacts with the spindle microtubules to ensure proper chromosmal segregation.