is approved for the treatment of depression.
Phenelzine (Nardil[R]), tranylcypromine (Parnate[R]), isocarboxazid
(Marplan[R]), and selegiline (Eldepryl[R]) are the MAOIs.
The MAOIs currently available in the United States are phenelzine (Nardil), isocarboxazid
(Marplan), and tranylcypromine (Parnate).
Sertraline and isocarboxazid
cause a serotonin syndrome.
There are three categories of these drugs: (1) TCAs (tricyclic antidepressants), which include imipramine (Tofranil) and amitriptyline (Elavil); (2) MAOIs (monoamine oxidase inhibitors), such as phenelzine (Nardil) and isocarboxazid
(Marplan); and (3) SSRIs (selective serotonin reuptake inhibitors), such as fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil).
Includes phenelzine oxidase, an enzyme that breaks (Nardil), isocarboxazid
antidepressant drugs such as isocarboxazid
, the Parkinson's medication selegiline, or the.
(2) The Sequenced Treatment Alternatives to Relieve Depression (STARED) study demonstrated that <50% of MDD patients achieve remission in monotherapy trials of selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, mirtazapine, or bupropion, necessitating consideration of antidepressant combinations, augmentation options, and eventually irreversible, nonselective MAOIs such as phenelzine, tranylcypromine, or isocarboxazid
. (3,4) Nonselective MAOIs thus offer a therapeutic opportunity for patients who do not respond to single or dual-mechanism strategies; moreover, nonselective MAOIs have compelling effectiveness data for other conditions, including panic disorder and social phobia.
A recent meta-analysis2 found no benefit over placebo of the ADs paroxetine, fluoxetine, amitriptyline and isocarboxazid
- studied specifically in patients with 'minor' depression.
John's wort, meperidine, and tryptophan) or a drug that exhibits monoamine oxidase inhibition properties (isocarboxazid
, linezolid, phenelzine, phentermine, selegiline, and tranylcypromine) may lead to serotonin syndrome.
Monoamine Oxidase * Combining with too * Avoid excessive Inhibitors much caffeine, beer or caffeine; use with isocarboxazid
wine (even alcohol- caution.
Irreversible MAO inhibitors include phenelzine, tranylcypromine, isocarboxazid
, hypericin, and nialamide, all of which are non-specific.
These drugs include phenelzine, isocarboxazid
, and tranylcypromine. Newer reversible drugs can reduce this complication of food monoamines significantly.