The most frequent VFs were the adhesins (97%), followed by the protectins (86%) and the iron acquisition systems (82%), while toxins, and invasins
were seldom detected (35 and 12%, respectively).
If inhabiting an environment of around 25 degree Celsius, the protein RovA ensures that the Yersinia bacteria form invasin
as a surface protein, which ensures that the bacteria can penetrate the intestinal cells immediately upon reaching the 37 degree Celsius intestine via food.
By binding to those bacterial surface receptors, Isberg's team found, invasin
switches on reactions in host cells that probably rearrange the network, in effect opening the door.
His laboratory was the first to describe the combination of invasin
and listeriolysin to enable Escherichia coli as a gene therapy tool.
The genes code for invasin
and Yop1, proteins found at the surface of Y.
pyogenes and SDSE in human hosts because it acts as an adhesin, invasin
, and antiphagocytic factor (11).
by its discoverers, the newly described protein is necessary for the bacterium Yersinia pseudotuberculosis to penetrate epithelial cells, say scientists from Tufts University School of Medicine in Boston and Stanford University School of Medicine.
Based on our understanding of the gene networks that control fungal invasion, we have developed novel Anti-Invasin
(TM) compounds that cripple these serious pathogens," said Angelika Fretzen, Senior Scientist, Anti- Invasin