Incidental serous tubal intraepithelial carcinoma
and early invasive serous carcinoma in the nonprophylactic setting: analysis of a case series.
Caption: A mucinous borderline tumor of the ovary with intraepithelial carcinoma
Validation of an algorithm for the diagnosis of serous tubal intraepithelial carcinoma
21 July 2014 - A study, carried out by US and Chinese scientists and published yesterday in Journal of Experimental &Clinical Cancer Research, has demonstrated that the oncoprotein, IMP3, could be participating in the process and progression of pelvic high-grade serous carcinoma (HGSC) and may be a complimentary biomarker in detecting serous tubal intraepithelial carcinoma
TP53/p53 abnormalities are believed to be initiating events in the development of serous endometrial cancer on the basis of their occurrence in premalignant cells, in endometrial glandular dysplasia, and in endometrial intraepithelial carcinoma
[reviewed in (24)].
They found serous tubal intraepithelial carcinomas
in 33% to 59% of these women.
A Randomized, Single Blind Placebo Controlled Phase 2 Study to Assess the Safety, Efficacy, and Immunogenicity of Vaccination with Listeria monocytogenes Expressing Human Papilloma Virus Type 16 E7 (Lovaxin C) for the Treatment Cervical Intraepithelial Carcinoma
Serous endometrial intraepithelial carcinoma
(A) and serous endometrial carcinoma (C) show strong, diffuse nuclear immunoreactivity with p53 in most cases (B and D) (hematoxylin-eosin, original magnification X10 [A and C]; original magnifications X4 [B] and X10 [D]).
Molecular and genetic analysis of these serous tubal intraepithelial carcinoma
(STIC) cells found p53 mutations that were identical to those in concurrent "ovarian" tumors.
A provisional of intraepithelial carcinoma
was made and wide excision was performed.
Serous intraepithelial carcinoma
of the endometrium is considered an early form of malignancy with an approximately 5% risk of recurrence following surgical staging.
Endometrial intraepithelial neoplasia should never be confused with endometrial intraepithelial carcinoma
, which refers to serous carcinoma and is driven by a p53 mutation.
Some cases contained foci of endometrial intraepithelial carcinoma
Entities to Be Considered in the Diagnosis of Tubal Intraepithelial Carcinoma
Reactive hyperplasia and atypia of the tubal epithelium Surgical (thermal) and histologic artifacts Arias-Stella phenomenon of tubal epithelium Radiation effects on tubal epithelium Tubal metaplasias--papillary metaplastic tumor and transitional metaplasia Atypical hyperplasia/tubal atypia Secretory hyperplasia of tubal epithelium Papillary syncytial metaplasia of tubal mucosal endometrium
Subsequent descriptions of the "earliest histologic changes of cervical cancer" as surface carcinoma or intraepithelial carcinoma
, and later carcinoma in situ (CIS), reflected the histologic descriptions of cells that morphologically looked like cancer but had not invaded below the basement membrane [17-19].