Similar intraepithelial carcinoma
cells were present in the endometrium as continuous and skip patterns and in the left fallopian tube as a partial lesion.
Serous tubal intraepithelial carcinoma
: its potential role in primary peritoneal serous carcinoma and serous cancer prevention.
21 July 2014 - A study, carried out by US and Chinese scientists and published yesterday in Journal of Experimental &Clinical Cancer Research, has demonstrated that the oncoprotein, IMP3, could be participating in the process and progression of pelvic high-grade serous carcinoma (HGSC) and may be a complimentary biomarker in detecting serous tubal intraepithelial carcinoma
TP53/p53 abnormalities are believed to be initiating events in the development of serous endometrial cancer on the basis of their occurrence in premalignant cells, in endometrial glandular dysplasia, and in endometrial intraepithelial carcinoma
[reviewed in (24)].
Crum, "Advances in the recognition of tubal intraepithelial carcinoma
: applications to cancer screening and the pathogenesis of ovarian cancer," Advances in Anatomic Pathology, vol.
They found serous tubal intraepithelial carcinomas
in 33% to 59% of these women.
The pathology and molecular biology of anal intraepithelial neoplasia: comparisons with cervical and vulvar intraepithelial carcinoma
. Int J Colorectal Dis.
High-grade dysplasia, intraepithelial carcinoma
, and carcinoma in situ were considered equivalent entities .
In their study, Marshall and colleagues reported that intraepithelial carcinoma
coexisted with a "benign appearing" urethral caruncle in only 1 of 376 patients who underwent a urethral caruncle resection.[sup.6] This is the only report of intraepithelial carcinoma
arising from a urethral caruncle found in the English literature.
Most interesting in this series was the presence of concurrent serous tubal intraepithelial carcinoma
(STIC) in 5 cases with identical TP53 missense mutations in the STIC and cervical lesions in 2/3 cases from the postmenopausal group.
The most common ovarian tumor in these patients is high-grade serous carcinoma which is believed to arise from a precursor lesion of fimbriae known as serous tubal intraepithelial carcinoma
Molecular and genetic analysis of these serous tubal intraepithelial carcinoma
(STIC) cells found p53 mutations that were identical to those in concurrent "ovarian" tumors.
A provisional of intraepithelial carcinoma
was made and wide excision was performed.
Pathologic assessment of prophylactic bilateral salpingo-oophorectomy and staging oophorectomy specimens is critical to identification of precursor lesions in ovarian cancer, known as serous tubal intraepithelial carcinoma
. A protocol for sectioning and extensively examining the fimbriated end (SEE-Fim) is commonly used in processing those specimens.
These tumors demonstrate an interesting morphologic homology with mucinous tumors of the ovary, a fact that is reflected by the diagnostic entities proposed by Amin et al (14): (1) mucinous cystadenoma; (2) mucinous cystic tumor of low malignant potential (MCTLMP), with or without intraepithelial carcinoma
(IEC); and (3) mucinous cystadenocarcinoma with either microinvasion or frank invasion.