Treadmill exercise and resistance training in patients with peripheral arterial disease with and without intermittent claudication
: a randomized controlled trial.
class="MsoNormalspan xml:lang="EN-GBSmoking causes inflammation of the arterial wall which is followed by formation of tiny clots which in turn obliterate the artery, causing intermittent claudication
to start with and eventually lead to gangrene due to less blood flow to the limbs.
Correlation between physical activity levels of patients with intermittent claudication
estimated using the Baltimore Activity Scale for Intermittent Claudication
and a pedometer.
There are several case reports of PAN among adults, who presented with rapidly progressive intermittent claudication
Guralnik et al., "Treadmill exercise and resistance training in patients with peripheral arterial disease with and without intermittent claudication
: a randomized controlled trial," JAMA, vol.
The 2004 Heart Outcomes Prevention Evaluation (HOPE) study indicates that ramipril maintains a mortality benefit for patients with intermittent claudication
. (5) A subgroup of this study included 1725 patients with baseline peripheral artery disease who were randomized to ramipril at 10 mg, which yielded a relative risk (RR) of 0.75 (95% CI, 0.61-0.92) for the primary outcome (cardiovascular mortality, myocardial infarction, stroke).
Twenty nine patients with intermittent claudication
were subjected to Doppler ultrasonography and followed by MDCT angiography.
Additionally, both the total and diagnosed prevalent cases of PAD are further segmented in symptomatic PAD, asymptomatic PAD, PAD with intermittent claudication
(IC), PAD with critical limb ischemia (CLI), PAD with hypertension, and PAD with diabetes.
[USPRwire, Mon Oct 05 2015] Global Markets Direct's, 'Intermittent Claudication
- Pipeline Review, H2 2015', provides an overview of the Intermittent Claudication
's therapeutic pipeline.
The US patent, which has been assigned the patent #9,096,827, protects specific methods of culturing placental adherent stromal cells and use of these cells for the treatment of several ischemic conditions, including heart disease, stroke, peripheral arterial disease (which includes critical limb ischemia and intermittent claudication
), graft-versus-host disease, solid organ transplantation, hematopoietic stem cell transplantation, diabetes, autoimmune diseases, neuropathic pain and cancer.
The common presentation is a male patient in his 40s who presents with intermittent claudication
without risk factors for atherosclerosis.
Atherosclerosis in the leg arteries can restrict blood flow and cause the legs to cramp during walking--a condition called intermittent claudication
. Most patients are treated with medications to dilate the arteries and exercise to help grow new blood vessels.
Peripheral vascular disease may be frequently associated in diabetes mellitus type II with its main symptom, intermittent claudication
. Many studies have reported the known efficacy of cilostazol in treating vascular claudication.
. N Engl J Med 2007;356:1241-50.
Pain and fatigue caused by clogged arteries in the legs is called intermittent claudication
. It's caused by atherosclerosis and inflammation.