(IS) is a distinctive disorder, which affects the individual during infancy and early childhood.1,2 It is one of the severe epilepsies of childhood and is indicative of a true Epileptic Encephalopathy.3 The incidence of infantile spasms
is one per 2000-6000 live births.4,5 Infantile spasms
usually develops before 12 months of age, with only 8% of cases occurring in children above one year of age.6 It is characterized by abrupt, symmetric flexion and/or extension of the neck, trunk and extremities.
The present study showed that generalized seizures (58%) were most common followed by focal (32%), absence (4%), unclassified (4%)and myoclonic seizures (1%), infantile spasm
(1%) (p value 0.174).
One third of the clinical picture of epilepsy is in the form of infantile spasm
, and 69% of this group had their first seizure before the age of one year (13).
(West syndrome): update and resources for pediatricians and providers to share with parents James WBMC Pediatric 2012, 12:108.
West Syndrome was also ruled out since she did not have infantile spasms
And, in a further blow, doctors confirmed Mia has the most severe case of the disease that causes a child to have infantile spasms
, fits, physical and mental problems.
At the time of diagnosis, the most common seizure type is infantile spasm
which is observed in 36-69% of the patients (26).
is a fully integrated specialty pharmaceutical company that serves the needs of the acute care and critical care hospital market with its proprietary products including Glofil(TM)-125 and Inulin for measuring renal GFR, Ethamolin(R)for sclerotherapy, HP Acthar(R)Gel to treat a seizure complex, referred to as West syndrome or infantile spasm
, and Pramidin(R)for various gastrointestinal disorders.
With growing body of evidence and introduction of diet modifications, ketogenic diet was promoted as a first line treatment for epileptic encephalopathies such as myoclonic-astatic epilepsy, Dravet syndrome and infantile spasm
. (Turk Arch Ped 2013; 48: 275-280)
If there is mental retardation with infantile spasm
, it is called West syndrome which is more non-responsive to treatment than the idiopathic variety, he added.
Global Markets Direct's, 'Infantile Spasm
(West Syndrome) - Pipeline Review, H1 2016', provides an overview of the Infantile Spasm
(West Syndrome) pipeline landscape.
Improvement in cognition in infantile spasm
has not been mentioned much except for papers which reported improvement in cognition and behavior with vigabatrin treatment, when the cause of infantile spasm
was tuberous sclerosis (10).
- Infantile Spasm
(West Syndrome) Global Clinical Trials Review, H1, 2014
[ClickPress, Fri Jul 25 2014] GlobalData's clinical trial report, "Infantile Spasm
(West Syndrome) Global Clinical Trials Review, H1, 2014 provides data on the Infantile Spasm
(West Syndrome) clinical trial scenario.
I--Characteristics of epilepsy: the age at the time of the first seizure and the type of the first seizure, seizure types, frequencies and durations observed in the follow-up, history of presence of infantile spasm
, antiepileptic drugs used in order.