At high concentrations (> 50 [micro]M), arsenic is able to induce
an apoptotic response in vitro, a phenomenon probably exploited in its use to treat leukemia (Jimi et al 2004; Lunghi et al 2004).
Gemin X is also developing small molecules that induce
apoptosis in p53-defective cancers.
The compound was found to induce
apoptosis in all 12 cell lines tested and in the first and only primary myeloma sample tested thus far.
a highly coordinated transcriptional program that orchestrates a cascade of cellular events related to uterine growth.
Encouraged by their success with strontium, the researchers tried another atomic gas, using a commercially available laser to induce
transparency in lead vapor contained in a molybdenum cell heated to 1,150[degrees]C.
For EP only, the 10,000 [micro]g/kg dose was able to significantly induce
luciferase activity when measured with MS after 8 hr (Figure 1).
For example, if a patient is two weeks beyond Naegele's rule for a due date, [the obstetrician] might induce
labor for post-maturity" without realizing the infant is actually only a week overdue.
Similarly, in eye diseases that are characterized by abnormal blood vessel growth, CA4P has been shown in preclinical studies to suppress development and induce
regression of these undesirable blood vessels.
Since then, vanadium has been found to regulate the activity of various enzymes that induce
pronounced changes in metabolic functions.
Indeed, until now, all that's been known is that there is something in the extracts of certain mammalian organs that has the ability to induce
differentiation (normal maturation) in cultured leukemic cells.
The TEF approach for risk assessment of HA compounds is mechanism based because the compounds of concern all act through a common aryl hydrocarbon (Ah) receptor (AhR) and induce
a common set of AhR-mediated responses.
4 PTZ exposure cause brain damage and induce
epileptic seizures by affecting specific receptors and the magnitudes of seizure differ in the developing brain as compared to the mature brain.
To see whether 5'AMP could induce
torpor, the researchers injected a synthetic version of the compound into animals on normal feeding and activity schedules.
As a result, those who adhered to the hydrogen hypothesis considered that other undetermined factors also were at work to induce
the hydrogen gas defect.
5 hr and disappears after 3 hr) may induce
neuronal degeneration resembling the delayed and progressive nature of the symptoms in patients with Parkinson's disease (Gao et al.