The company's preclinical programmes attack components of the IDO and TDO pathways by targeting their resultant immunosuppressive
metabolite kynurenine as well as a downstream receptor.
Here, we present the case of a patient who was receiving immunosuppressive
drugs for polyarteritis nodosa and developed cytomegalovirus pneumonia with pulmonary haemorrhage.
Clinical indications for immunosuppressive
treatment in AIH patients with liver cirrhosis, particularly those with decompensated cirrhosis and severe complications, remain difficult to specify, largely due to our limited knowledge of the long-term outcomes of these patients after treatment.
Experts from the Transplant Roundtable believe that immunosuppressive
drugs unequivocally meet both of the standards set forth for protected class status in the Proposed Rule.
Their study was conducted to optimize an immunosuppressive
protocol for transplanting human spinal cord cells into presymptomatic ALS G93A rats with the G93A superoxide dismutase (SOD1) mutation.
Assess VZV infection and vaccination history, especially in those patients likely to use high-dose immunosuppressive
therapy or biologic agents.
These are patients who had stopped taking their prescribed immunosuppressive
medications for at least a year, yet did not reject their kidneys.
Before patients go on immunosuppressive
treatment, they should be screened for hepatitis B surface antigen (HBsAg).
The fibrocalcific nodules found on the chest radiograph imply that either 1) the patient might have had histoplasmosis for years and it became disseminated because of immunosuppressive
therapy for rheumatoid arthritis or 2) the patient was reinfected with the calcified lesions that resulted from prior histoplasmosis.
Only physicians experienced in immunosuppressive
therapy and management of renal, cardiac or hepatic transplant patients should use CellCept.
In some Latin American countries, discontinuation of treatment when immunosuppressive
drugs are unavailable can cause late renal graft loss.
Furthermore, patents are pending in 15 additional countries relating to TAFA93, the company's second immunosuppressive
The support stops with the patients' most critical need maintaining a supply of immunosuppressive
Previous studies have demonstrated that the clinical response to immunosuppressive
drugs, in terms of both efficacy and drug-related toxicity, may vary substantially even in patients with similar blood concentrations of immunosuppressive