immunogenicity


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Related to immunogenicity: humoral immunity
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  • noun

Words related to immunogenicity

the property of eliciting an immune response

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References in periodicals archive ?
CpG (a hexameric motif) adjuvant can effectively improve the immunogenicity of DNA vaccine (Lipford et al., 1997; Davis et al., 1998; Li et al., 2016).
Sofie co-founded ImmunXperts in 2014 with the aim of supporting drug development processes in the fields of immuno-oncology, immunogenicity assessments and cellular therapy.
As at now, we are doing clinical and laboratory assessment for safety issues and also testing immunogenicity to see whether the vaccine can provoke an immune response in the body, said Dr Josphat Kosgei, the Associate Investigator at Kemri.
Search terms included "Heplisav," "HBV-ISS," "HBsAg-1018," "1018 immunostimulatory sequence," and "hepatitis B surface antigen-1018 ISS." To qualify as a candidate for inclusion in the review, a study had to present immunogenicity or disease endpoints or safety data on HepB-CpG.
Chemical modifications to the biologic, including antibody drug conjugates may be seen as a non-self antigen by the body and cause immunogenicity. Manufacturing can also contribute.
Prespecified antibody titers were set conservatively to ensure adequate immunogenicity. Noninferiority criteria had to be met for all 9 HPV types.
After vaccination, in adults and older adults, the hemagglutination-inhibition titers fulfilled the European licensure criteria for immunogenicity. In adults, the seroprotection rates with HI titer [greater than or equal to]1:40 were 100% (A/H1N1), 98.4% (A/H3N2), 100% (B/Yamagata), and 100% (B/Victoria); in older adults were 94.7% (A/H1N1), 96.5% (A/H3N2), 100% (B/Yamagata), and 100% (B/Victoria).
Despite containing predominantly human sequences, these molecules may show structural features that are different from those of the endogenous proteins, such as glycosylation patterns that are characteristic of the producing cells [Chinese hamster ovary (CHO) cells or mouse myeloma cells] and not necessarily identical to the human glycosylation pattern, which may also contribute to immunogenicity (14).
Immunogenicity, suboptimal dosing, low serum drug levels, and intermittent or episodic therapy have been documented as explanations for this phenomenon.
It also brings on board IPM's immunogenicity, pharmacokinetics, and pharmacodynamics expertise to complement BioAgilytix's capabilities in biomarkers, cell-based assays, and immunogenicity and pharmacokinetics.
The researchers showed that the abnormal expression of immunogenic antigens in smooth muscle cells, but not in retinal pigment epithelium cells, contributes to the differential immunogenicity.
PROPOSED REVISIONS TO THE GUIDELINE ON THE ASSESSMENT OF IMMUNOGENICITY FOR BIOTECHNOLOGY DERIVED PROTEINS AND ITS RELEVANCE TO BIOSIMILARS
Antitope Limited, an Abzena company, has collaborated with Synthon Biopharmaceuticals BV (Synthon), a global pharmaceutical company with expertise in the development of complex small molecule and biosimilar drugs and new biopharmaceuticals, including antibody drug conjugates (ADC), to assess the potential immunogenicity of candidate antibodies for Synthon's ADC programmes.