Hypothalamic gray matter volume loss in hypnic headache
Previous studies have shown that patients with episodic migraine may present alterations in blink reflex, particularly regarding habituation to the stimulus, while TTH, cluster headache, cervicogenic headache and hypnic headache
all presented negative or controversial information on the blink reflex responses.
The investigators found that lithium had the highest positive response rate of all treatments, with 70% of study subjects experiencing complete response and 20% experiencing moderate response, defined as more than a 50% improvement in the frequency and intensity of hypnic headache
Indeed, the drug has also been proved to be effective as a preventive treatment of migraine, hypnic headache
, CH and SUNCT but the exact mechanism of topiramate in prophylactic treatment for various headache syndromes are not well known.
Another type of primary headache, the hypnic headache
, has been reported specifically in the elderly and not in younger age groups.
A variety of headache disorders result in nocturnal headache: migraine, cluster headache, chronic paroxysmal hemicrania, and hypnic headache