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Earlier, the pathophysiology of thrombocytopaenia in liver disease was linked to the presence of hypersplenism, but now it has been discovered that thrombopoietin production is dependent on functioning liver cell mass and is responsible for reduced thrombopoiesis and consequently peripheral thrombocytopaenia.
sup],,,, Liver cirrhosis and its associated hypersplenism are common among liver transplant recipients.
In our study more than half of the patients had hypersplenism and had documented decrease in number of platelets and white cell counts.
Hypersplenism: Hypersplenism is a condition in which the spleen becomes increasingly active and then rapidly removes the blood cells.
Impact of antithrombin III concentrates on portal vein thrombosis after splenectomy in patients with liver cirrhosis and hypersplenism," Annals of Surgery, vol.
G-CSF is used in treatment, but it should be kept in mind that hypersplenism requiring splenectomy may occur in long-term use (1, 3, 4, 7, 9).
Anemia and thrombocytopenia in patients with HSTL have largely been attributed to hypersplenism and to infiltration of the bone marrow by neoplastic cells; however, cytokines may also be involved.
malaria), drug- or toxin-induced hemolysis, hypersplenism, and Wilson disease (4).
In this study the leading causes were dengue followed by malaria, chronic liver disease, hypersplenism, and septicemia.
Such diverse pathologic causes can be present in different diseases such as aplastic anemia (AA), megaloblastic anemia (MA), myelodysplastic syndromes (MDS), acute leukemia, hairy cell leukemia, myelofibrosis with myeloid metaplasia (MMM), lymphomatous or metastatic involvement of bone marrow, leishmaniasis, hemolytic diseases such as systemic lupus erythematous (SLE), hypersplenism and many other diseases.
Excessive destruction occurs in autoimmune ITP SLE viral infections like EBV dengue and HIV DIC TTP and in hypersplenism.
Therefore, the combining effects of ineffective erythropoiesis, hemolysis, and hypersplenism are the main culprit of severe anemia in [beta]-thalassemia patients .
Rarely, the enlargement of the spleen is more pronounced with hypersplenism and pancytopenia [8, 14].
Liver involvement is a result of congenital hepatic fibrosis or Caroli disease, which may progress to portal hypertension, hypersplenism with resultant thrombocytopenia and recurrent ascending cholangitis (Caroli syndrome).
The nuclear medicine liver spleen scan with Tc-99m sulfur colloid was useful to show splenomegaly and colloid shift with an increased spleen to liver ratio suggestive of hypersplenism (Figure 3).
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