According to that found in this study, various aspects should be revised for the work of nurses to correspond to humanized
In the study, Paul Denton, instructor of medicine and colleagues provide data that validates humanized
BLT mice as a preclinical experimental system that potentially can be used to develop and test the effectiveness of experimental HIV prevention approaches and topical microbicides.
The Company will present XmAb5485 data in an oral presentation titled, "An Fc-Engineered Humanized
Anti-CD40 Monoclonal Antibody, XmAb5485, Exhibits Potent Activity In Vitro and In Vivo Against Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia and Multiple Myeloma," on Tuesday, December 9 at 7:15 a.
Patent 8,486,395 covering the use of proprietary humanized
hA19 antibody for the treatment of B-cell lymphoma, chronic lymphocytic leukemia or acute lymphocytic leukemia.
The license was granted under the terms of an agreement announced by the two companies in January 2000 covering certain intellectual property in the field of humanized
antibodies, and triggers payment of an additional license fee to Protein Design.
Additionally, the Company is developing a humanized
monoclonal antibody, Angiolix, which appears to induce cell death selectively to tumor blood vessels using a different mode of action than VEGF-oriented therapies.
In addition, Protein Design has already entered into patent or patent rights agreements in 2000 covering up to nine humanized
SGN-40 is a humanized
monoclonal antibody currently in Phase I and Phase II clinical trials for multiple myeloma, chronic lymphocytic leukemia and non-Hodgkin's lymphoma.
Mylotarg will become the fourth humanized
antibody to be marketed in the United States"
PRO 140 is a humanized
monoclonal antibody that binds CCR5, a principal portal used by HIV to enter cells and a promising target for a new generation of HIV therapies.
Merck is the twenty-eighth company to have signed an agreement with Protein Design related to humanized
antibodies and our antibody humanization patents," said Robert L.
SGN-33 (lintuzumab) is a humanized
monoclonal antibody that targets the CD33 antigen.
Fremont, CA) announced that it has entered into a patent rights agreement with Celltech Chiroscience plc (Celltech) covering certain intellectual property in the field of humanized
SGN-33 modulates cytokine and chemokine production by activated monocytes and macrophages Poster session on Sunday, December 10, 2006; 9:00am - 8:00pm ET Abstract: #1995 -- Increased dose intensity of SGN-33, a humanized
monoclonal antibody targeting CD33, is active and well-tolerated in patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) Abstract # 4568 (publication only)
This technology can be used to alter functional properties of antibodies in desirable ways, independent of whether the antibody is chimeric, humanized
, or fully human.