Adrenocorticotropic hormone resistance
syndrome was considered in our patient with the hormone tests performed because of hypoglycemia.
Evidence of hormone resistance
in a pseudo-pseudohypoparathyroidism patient with a novel paternal mutation in GNAS.
Laron Z: Laron syndrome (primary growth hormone resistance
or insensitivity): the personal experience 1958-2003.
Evidence for the secretion of thyrotropin with enhanced bioactivity in syndromes of thyroid hormone resistance
Thyroid hormone resistance
syndrome: Correlation of dominant negative activity and location of mutations.
Rare causes of inappropriate TSH include TSH-secreting pituitary tumours and syndromes of thyroid hormone resistance
Type Ia is the most common type which is an autosomal dominant condition it has phenotypic features of AHO with hormone resistance
and decreased nephrogenic cAMP response to PTH and GNSA 1 mutation as well.
However, when these fragile feedback mechanisms become overwhelmed and fail, hormone resistance
actually favors weight gain.
Whilst around 50% of metastatic breast cancers will display an intrinsic resistance to hormone therapies despite being hormone receptorpositive (de novo resistance), more than one-third of patients with endocrine-responsive, early-stage breast cancer, and almost all of those with metastatic disease, will develop hormone resistance
during the course of their disease (acquired resistance) [5-7] despite an initial response to the therapy--resulting in disease relapse and progression.
In anorexic patients, IGF-I levels decrease, and patients acquire growth hormone resistance
One postulated mechanism for thyroid hormone resistance
found in WTS/CFS might be due to a dysregulation in the type I interferons (IFN-alpha/beta) pathway.
Increased clusterin expression protects prostate cancer cells from the cytotoxic effects of hormone ablation and chemotherapy and elevated levels of clusterin are associated with hormone resistance