In the case of this patient, though leuprolide was very well tolerated for an extended period of time, the choice was eventually made to transition to finasteride due to concerns about long term effects of hormonal manipulation
. Finasteride, a 5a-reductase inhibitor, has been described as an effective prophylactic therapy for recurrent priapism, though the mechanism by which it acts in this context is unclear (5).
Trifiro, "Hormonal manipulation
of benign metastasizing leiomyomas: report of two cases and review of the literature," The Journal of Clinical Endocrinology & Metabolism, vol.
Metastasizing leiomyoma of the uterus and hormonal manipulations
: case report.
Broodstock management and hormonal manipulation
of fish reproduction.
They discuss the hormonal manipulation
involving gut hormones as a promising treatment of obesity without surgery.
Through processes that included psychological evaluation and hormonal manipulation
to prepare the body, an egg from Emily and a sperm from her husband were implanted in the uterus of Emily's mother.
Orthodox medical therapies for endometriosis generally revolve around hormonal manipulation
and these provide variable results.
A history of recent hormonal manipulation
for the treatment of infertility may be associated with the development or the progression of this rare tumor.