histocompatibility complex

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  • noun

Words related to histocompatibility complex

a family of fifty or more genes on the sixth human chromosome that code for proteins on the surfaces of cells and that play a role in the immune response

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References in periodicals archive ?
Identification and evaluation of major histocompatibility complex antigens in chicken chimeras and their relationship to germline transmission.
The revealed differences in the content of soluble molecules of the major histocompatibility complex in COPD patients depending on the severity degree and the disease period allow us to consider these proteins as potential biomarkers of activation of local and systemic inflammation and severity of COPD.
Abbreviations HLA - human leucocyte antigens MHC - major histocompatibility complex WHO - World Health Organization CDC - complement dependent cytotoxicity PCR - polymerase chain reaction TRALI - transfusion related acute lung injury vCJD - variant Creutzfeldt-Jakob disease History
Mathis, "Regulation of major histocompatibility complex class-II genes: X, Y and other letters of the alphabet," Annual Review of Immunology, vol.
The first signal required for T-cell activation is antigen presentation via the major histocompatibility complex on antigen-presenting cells (APCs).
The immunohistochemical staining for major histocompatibility complex class 1 was equivocal.
In humans, major histocompatibility complex controlled by the genes located on chromosome 6 is responsible for ensuring compatibility between donors and recipients.
Cathepsin S is involved in the assembly of the major histocompatibility complex II protein, and by interfering with this process, the effector T-helper cell response may be muted and T-cell interaction with B cells may be decreased.
(2) One of these risk genes, on chromosome 6, is in the major histocompatibility complex and has the strongest association with schizophrenia (P = [10.sup.-31]).
Natural selection at major histocompatibility complex loci of vertebrates.
Called the major histocompatibility complex, or MHC, this DNA chunk carries information used by the immune system to help identify invaders.
AIT specializes in generating and developing T-Cell Receptor-Like antibodies with high affinity and specificity to disease-specific intracellular peptides presented on the cell surface by the major histocompatibility complex.
Specialized cells in the thymus interact with a molecule known as the Major Histocompatibility Complex class II (MHCII) to "teach" T cells to differentiate between normal tissues and organs, and foreign invaders.
PLX cells, and other MSC, affected complex pathways in order to prevent the priming of Type 1 T helper cell (Th1) responses towards major histocompatibility complex mismatches.
Indeed, the human leucocyte antigen (HLA) region, the major histocompatibility complex (MHC) in humans, was initially suggested as an RA-associated locus in 1976.