hepatotoxic

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Words related to hepatotoxic

toxic to the liver

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References in periodicals archive ?
In addition, the protective effect of the selective FXR agonist GW4064 on triptolide-induced hepatotoxicity was explored in BALB/c mice.
Hepatotoxicity may result from direct toxicity of the primary compound, a metabolite, or from an immunologically mediated response, affecting hepatocytes, biliary epithelial cells and/or liver vasculature.
At a pragmatic level, pretreatment and posttreatment bilirubin levels in these patients could be evaluated to provide an indication of what the background bilirubin level was in the affected samples during treatment, especially if there was no clinical evidence of hepatotoxicity and if other liver-related markers were unchanged.
8-10) This type of presentation is felt to represent a form of occult hepatotoxicity relating to niacin.
We therefore diagnosed drug-induced hepatotoxicity caused by aspirin.
The effects of reactive metabolites to elicit hepatotoxicity are included in v1A of the DILIsym[TM] model, with multiple drugs (e.
The committee members were particularly concerned about an increased incidence of neoplasm serious adverse events--new malignant events--in the group on 100-mg mirabegron in the 1-year study, as well as hepatotoxicity events and hypersensitivity reactions.
Previously, only three cases were reported in English literature about mirtazapine induced hepatotoxicity (5,6).
Drug-induced liver injury (DILI) is a term increasingly being used by most clinicians and is synonymous with drug-induced hepatotoxicity.
However, because of reports of hepatotoxicity, the risk/benefit ratio has appeared to be too high for use in clinical practice.
4] -induced hepatotoxicity serves as an excellent model to study the molecular, cellular and morphological changes in the liver [2].
These have been linked to hepatotoxicity and liver injury.
In addition to the anti-tuberculosis and positive clinical effects, Immunitor's V5 immunomodulator is also shown to reduce the hepatotoxicity induced by chemotherapy for TB, MDR-TB and XDR-TB.
For example, depending on the specific combination of medications used, up to 30 percent of patients experience severe hepatotoxicity after initiation of their HAART treatment, as indicated by at least a fivefold elevation of liver enzyme levels in the blood (2) (Sulkowski et al.
Anti-TB drug induced hepatotoxicity (DIH) is the most common side-effect leading to interruption of therapy (2).