Jaffe was the first to describe pigmented villonodular synovitis (PVNS) as a chronic proliferative disease that occurs in the joint, tendon and bursa synovium.1 According to Jaffe, PVNS is characterised by thickened and hyper- plastic synovia organised into villi and nodules, which lead to the deposition of intra-cellular haemosiderin
Traditional beer was produced by fermenting maize (often with sorghum added) in iron containers that, as they rusted with the passage of time, released large quantities of iron into the beer, which was deposited in tissues as haemosiderin
.  A postmortem series demonstrated that the level of iron overload, reflected in the amount of haemosiderin
in the tissues in males and females dying of natural causes, correlated with traditional beer consumption.
The secretory cells may contain pigment which is neither melanin nor haemosiderin
. The secretions in the cysts may be coagulated and stained using the PAS technique.
This particular study obtained histopathological evidence that deposition of haemosiderin
occurred in the endometrial glandular epithelium of three patients with BTM .
Analysis of the urine sample revealed the presence of coluria and weakly positive haemosiderin
(Perls' reaction, Figure 1) indicating intravascular haemolysis, with absent bilirubin, and no red cells were seen under microscope.
The exact pathophysiological mechanisms underlying its development are unclear although epidermal atrophy, vasodilation, and dermal deposition of melanin and haemosiderin
have all been implicated .
Areas of T1 hyperintensity are present in acute haemorrhage with a characteristic haemosiderin
hypo-intense rim noted in the subacute stage.
provides a linkage amid copper and iron metabolism and mediates the discharge of iron from ferritin and haemosiderin
(Hays and Swenson, 1985).
Precisely the same mechanism operates at the level of the reticulum cell or macrophage, allowing re-utilisation or recycling of the iron recovered once old red cells have been removed from circulation and degraded, with temporary storage in ferritin or haemosiderin
The histological abnormalities noted in these patients include glomerular enlargement, haemosiderin
deposit, papillary necrosis, cortical infarction, focal segmental glomerulosclerosis, membranoproliferative glomerulonephritis, tubular atrophy, and interstitial fibrosis [14,17,18].
The World Health Organisation (2005) define a central giant cell granuloma as a benign intraosseous lesion consisting of fibrous tissue containing foci of haemorrhage and haemosiderin
deposits, aggregations of giant cells and reactive bone formation.
Iron from haemoglobin is deposited as haemosiderin
and causes a brown staining in the leg.
An electron microscopical study on the genesis of lipofuscin, melanin and haemosiderin
in the haemopoitic tissues of fish.
Other investigations used to identify the origin of the low T2 signal intensity foci (such as haemosiderin
and calcification) in the tumour include gradient echo MR images, T1-weighted MR images and CT imaging.
Successful reduction of hepatocellular haemosiderin
content in toco toucans (Ramphastos toco) with haemochromatosis by dietary modification.