Randomised trial of topical 0.2% glyceryl trinitrate
and lateral internal sphincterotomy for the treatment of patients with chronicanal fissure: Long-termfollow-up.
Dall'Oglio et al., "Topical glyceryl trinitrate
ointment for pain related to anal hypertonia after stapled hemorrhoidopexy: a randomized controlled trial," Diseases of the Colon & Rectum, vol.
Local application of 0.2% Glyceryl trinitrate
ointment can improve anodermal blood flow by inducing sphincter relaxation and thereby results in symptomatic relief and healing of fissure without compromising the anal continence.
Topical diltiazem hydrochloride and glyceryl trinitrate
in the treatment of chronic anal fissure.
and ritodrine in tocolysis: an international multicenter randomized study.
Topical application of glyceryl trinitrate
(GTN) ointment to the anal rim temporarily reduces resting anal sphincter pressure and promotes healing of fissures whilst minimising the risk of incontinence; however nitroglycerine has a significant risk of headaches.
p p Price for month's supply of cardiac drugs Co Donegal pharmacy Derry city pharmacy Aspirin 75mg EUR3.50 pounds 1.00 (EUR1.27) Clopidogrel 75mg EUR47.00 pounds 3.27 (EUR4.14) Simvastatin 40mg EUR13.50 pounds 3.00 (EUR3.80) Bisoprolol 1.25mg EUR9.50 pounds 3.53 (EUR4.47) Ramipril 1.25mg EUR9.50 pounds 3.00 (EUR3.80) e EUR13.00 pounds 3.30 (EUR4.18) Glyceryl Trinitrate
spray (1 bottle) Total EUR96.00 pounds 17.10 (EUR21.72) Total
(84) Topical glyceryl trinitrate
was effective in cases of chronic noninsertional Achilles tendinopathy, and the treatment benefits continued at 3 years.
Five studies compared glyceryl trinitrate
with placebo, one study compared nitroglycerin with local injection of a steroid-anesthetic solution, and one study evaluated topical nitroglycerin and tendon rehabilitation, compared with tendon rehabilitation alone.
Other agents such as sodium nitroprusside, glyceryl trinitrate
, clonidine and prazosin have been used but their unfavourable side-effect profile limits their clinical usefulness (4,5).
The study groups were as follows: group S--patients treated by open lateral internal sphincterotomy; group D--treated by local application of 2% diltiazem ointment twice a day for 4-6 weeks; group GTN--treated by local application of 0.2% glyceryl trinitrate
ointment twice a day for 4-6 weeks; and group BT -- treated by injection of botulinum toxin into the internal anal sphincter.
Continuing the cardiac theme, Fan et al examined cardiac patients' knowledge and use of sublingual glyceryl trinitrate
using the Sublingual Nitroglycerin Interview Schedule.
The problem can be made worse by the use of glyceryl trinitrate
or GTN sprays for angina, with some patients unable to distinguish between angina and a heart attack.
The glyceryl trinitrate
(GTN) treatment was given for angina and aspirin for anticoagulation.
The study, which he presented at the annual meeting of the Society for Gynecologic Investigation, randomized 158 women between 24 and 32 weeks" gestation and in preterm labor either to placebo (81 patients) or a transdermal nitroglycerin, or glyceryl trinitrate
(GTN), patch (77).