Similar phenomenon also existed in the lenses of rat galactosemic cataract model in vivo, and lots of vacuoles initially appeared around the lens equator and continuously expanded to anterior capsule during the early stage of sugar cataract.
As to rat galactosemic cataract model, few tiny vacuoles arose around the equatorial area from the 3rd day; subsequently, dense clusters of vacuoles began to expand to the anterior capsule by day 6.
Shen et al., "A simple and stable galactosemic cataract model for rats," International Journal of Clinical and Experimental Medicine, vol.
AR has higher affinity to galactose than to glucose; the metabolite galactitol is more poorly reduced by SDH than sorbitol, and it takes shorter time to form rat galactosemic cataract model than another one [3, 4, 18].
In previous studies, the galactosemic cataract was usually induced on adult rats by feeding 30-50% galactose chow; it took more than one month time to form this model [10, 14, 19].