The researcher also said the safety of GBCAs or gadolinium
contrast media in pregnant women "has not been established, and their use during pregnancy is not recommended unless essential to the health of the woman or fetus".
In this study, data on nearly 4.7 million live births in the United States between 2006 and 2017 found that gadolinium
exposure occurred in one in 860 of those pregnancies.
Gadavist, also known as Gadovist and Gadovist 1.0 in other regions, is the US brand name of the aqueous 1.0M solution of gadobutrol, a gadolinium
(Gd)-based extracellular contrast agent for MRI with a macrocyclic structure, disclosed the company.
The cyclic structure creates a stronger bond to gadolinium
. Macrocyclic agents have a cage-like structure that is less likely to release the Gd(III) ion.
It is meant to pass out of the body via the kidneys in the patient's urine, but there is evidence that some gadolinium
is retained in the body, where it can be deposited in bone, tissue and the brain.
(5) reported that 2 of 7 (29%) patients with CKD who developed AKI after gadolinium
exposure went on to long-term dialysis, fewer than the 60% observed in the current study.
The solid-state reaction was performed using gadolinium
acetate as the precursor, while in the case of sol-gel technique, apart from gadolinium
nitrate has also been used.
Human studies have revealed maximum plasma gadolinium
concentrations of 65.7 [micro]g/mL.
The initial molar fraction of gadolinium
ions in respect to total amount of iron and gadolinium
ions was varied from 0.5 to 9 mol.%.
Physicists hope that gadolinium
will help them to spot the relic neutrinos much more easily, by distinguishing their signals very clearly from everything else.
The study group underwent cardiac MRI exams with the contrast agent gadolinium
, which is taken up by both normal and injured heart muscle tissue.
The Pharmacovigilance Risk Assessment Committee (PRAC) of the European Medicines Agency (EMA) did not identify any adverse effects of brain retention of gadolinium
. Of the two types of gadolinium
, linear and macrocyclic, the PRAC-EMA recommended the former type no longer be marketed as it was associated with greater retention of the GBCA (FDA, 2017).
; (2) Working fluid/heat transfer fluid: transfers the heat to/from regenerator and heat exchangers e.g.
It showed an intramyocardial subepicardial signal anomaly in the anterior, inferoseptal, and anterolateral walls in T2 and in late gadolinium
enhancement in T1-weighted images (after 10 min of gadolinium
injection) suggesting acute toxic myocarditis (Figures 5(a) and 6).
The combination of gadolinium
exposures in concert with dialysis dependence was most likely the cause of his NSF.