Prozac (fluoxetine hydrochloride), Zoloft (sertraline hydrochloride), and Paxil (paroxetine hydrochloride) are selective serotonin reuptake inhibitors (SSRIs), medications that block serotonin--a neurotransmitter that controls mood--from being absorbed into brain cells.
IVAX Corporation (AMEX:IVX), Miami, Fla., has announced that the United States Food and Drug Administration (FDA) has given tentative approval to the company's ANDA for fluoxetine hydrochloride capsules in strengths of 10 mg and 20 mg.
Fluoxetine hydrochloride, a relatively new selective inhibitor of serotonin reuptake, has been shown to be effective in the treatment of depression.(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) Studies have proven fluoxetine to be more effective than placebo and equally as effective as tricyclics.(1)(2)(3)(4)(5)(6)(7)(11) However, there are no published clinical trials on the use of fluoxetine to treat depression in primary care settings.
Olanzapine and fluoxetine hydrochloride is the generic version of Eli Lilly and Co.'s Symbyax and is indicated for the acute treatment of depressive episodes associated with bipolar i disorder in adults.